Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-11-11
pubmed:abstractText
Dendritic cells (DCs) are potent antigen presenting cells and play critical role in T cell-mediated immunity. DCs have been shown to induce strong anti-tumor responses both in vitro and in vivo. Their efficacies in tumor therapy are being investigated in clinical trials. Previous evidence has shown that these DCs enhance the cytotoxicity of NK cells. We generated NK-like T cells (CD3(+)CD56(+)), a novel type of effector cells differentiated from normal lymphocyte, which is now being used for adoptive immunotherapy in clinical trials. This study aimed to elucidate the effects of NK-like T cells after co-culturing with DCs against tumor cells. The result revealed that tumor-derived RNA-pulsed DCs can enhance the immune responses of NK-like T cells against glioblastoma multiforme cell line but these effector cells did not appear to have the cytotoxic effect against normal cells (human umbilical vein endothelial cells (HUVEC) and fibroblasts) in vitro. This study may be beneficial for the development of new immunologic effector cells for using in adoptive immunotherapy for glioblastoma multiforme in the future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0167-594X
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16234988-Antigen Presentation, pubmed-meshheading:16234988-Antigens, CD3, pubmed-meshheading:16234988-Antigens, CD56, pubmed-meshheading:16234988-Cell Line, pubmed-meshheading:16234988-Cell Line, Tumor, pubmed-meshheading:16234988-Coculture Techniques, pubmed-meshheading:16234988-Cytotoxicity Tests, Immunologic, pubmed-meshheading:16234988-Dendritic Cells, pubmed-meshheading:16234988-Endothelial Cells, pubmed-meshheading:16234988-Endothelium, Vascular, pubmed-meshheading:16234988-Glioblastoma, pubmed-meshheading:16234988-Humans, pubmed-meshheading:16234988-Immunophenotyping, pubmed-meshheading:16234988-Immunotherapy, Adoptive, pubmed-meshheading:16234988-Killer Cells, Natural, pubmed-meshheading:16234988-Lymphocyte Activation, pubmed-meshheading:16234988-RNA, Neoplasm, pubmed-meshheading:16234988-T-Lymphocytes, pubmed-meshheading:16234988-Umbilical Veins
pubmed:year
2005
pubmed:articleTitle
Dendritic cells pulsed with total tumor RNA for activation NK-like T cells against glioblastoma multiforme.
pubmed:affiliation
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't