Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-10-19
pubmed:abstractText
We have demonstrated recently that CCL20 was expressed in periodontal diseased tissues and abundant CCR6 positive T cells infiltrated in periodontally diseased tissue. However, it is uncertain which cells can elicit CCL20 production. In the present study, we examined the properties of CCL20 production by human gingival fibroblasts (HGF) culture. Here, we report that interleukin-1 beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and Escherichia coli lipopolysaccharide (LPS) can significantly induce the production of CCL20 by HGF. We found that TNF-alpha and E. coli LPS enhanced the production of CCL20 by HGF treated with IL-1beta. In contrast, interferon-gamma (IFN-gamma) dramatically diminished CCL20 production induced by IL-1beta. Moreover, we demonstrated that nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases (ERK) play an important role in mediating the production of CCL20 induced by IL-1beta and TNF-alpha. On the other hand, we found that not only NF-kappaB, p38 MAPK and ERK but also c-Jun NH2-terminal kinase (JNK) are involved in CCL20 production induced by E. coli LPS. Finally, we found that HGF express CCR6, CCL20 receptor, and CCL20 induced vascular endothelial growth factor (VEGF) by HGF. Taken together, these findings that HGF will be a source of CCL20 in periodontal tissue, and the CCL20 production will be controlled by proinflammatory cytokine and bacterial LPS in periodontally diseased tissue. Thus, CCL20 by HGF might be involved in inflammatory cells infiltration, and promote the progression of periodontal disease.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-10064080, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-10225458, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-10362511, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-10467937, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-10521347, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-10770804, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-11035086, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-11133838, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-11274925, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-11449350, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-11472439, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-11481616, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-11581170, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-12067311, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-12695561, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-12760962, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-12821122, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-1331059, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-15069060, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-3863838, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-7891256, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-8406859, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9120310, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9169459, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9174597, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9223454, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9250144, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9294137, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9294138, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9495612, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9597130, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9670049, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9879517, http://linkedlifedata.com/resource/pubmed/commentcorrection/16232215-9886385
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CCL20 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL20, http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP..., http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein..., http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A, http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
142
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-91
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16232215-Humans, pubmed-meshheading:16232215-Gingiva, pubmed-meshheading:16232215-Lipopolysaccharides, pubmed-meshheading:16232215-Female, pubmed-meshheading:16232215-Enzyme Inhibitors, pubmed-meshheading:16232215-Adult, pubmed-meshheading:16232215-Fibroblasts, pubmed-meshheading:16232215-Cells, Cultured, pubmed-meshheading:16232215-RNA, Messenger, pubmed-meshheading:16232215-Gene Expression Regulation, pubmed-meshheading:16232215-Signal Transduction, pubmed-meshheading:16232215-Interferon-gamma, pubmed-meshheading:16232215-Interleukin-1, pubmed-meshheading:16232215-Cytokines, pubmed-meshheading:16232215-Tumor Necrosis Factor-alpha, pubmed-meshheading:16232215-Vascular Endothelial Growth Factor A, pubmed-meshheading:16232215-NF-kappa B, pubmed-meshheading:16232215-Macrophage Inflammatory Proteins
More...