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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-10-19
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pubmed:abstractText |
Aspergillus fumigatus (Af) is a fungus associated with allergic bronchopulmonary aspergillosis (ABPA) and other allergic diseases. Immune responses in these diseases are due to T and B cell responses. T cell activation requires both Af-specific engagement of the T-cell-receptor as well as interaction of antigen independent costimulatory molecules including CD28-CD80/CD86 and OX40-OX40L interactions. Since these molecules and their interactions have been suggested to have a potential involvement in the pathogenesis of ABPA, we have investigated their role in a model of experimental allergic aspergillosis. BALB/c mice were primed and sensitized with Af allergens, with or without exogenous IL-4. Results showed up-regulation of both CD86 and CD80 molecules on lung B cells from Af-sensitized mice (79% CD86+ and 24% CD80+) and Af/rIL-4-treated mice (90% CD86+ and 24% CD80+) compared to normal controls (36% and 17%, respectively). Lung macrophages in Af-sensitized mice treated or not with IL-4 showed enhanced expression of these molecules. OX40L expression was also up-regulated on lung B cells and macrophages from both Af-sensitized and Af/rIL-4 exposed mice as compared to normal controls. All Af-sensitized animals showed peripheral blood eosinophilia, enhanced total serum IgE and allergen-specific IgG1 antibodies and characteristic lung inflammation. The up-regulation of CD80, CD86 and OX40L molecules on lung B cells and macrophages from Af-allergen exposed mice suggests a major role for these molecules in the amplification and persistence of immunological and inflammatory responses in ABPA.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-10075870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-10088929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-10228138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-10380772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-10637280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-10696062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-10848921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-11029388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-11146389,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12672051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12672399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12787295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12798304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12848951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12860930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12911411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-12956753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-14674938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-14999428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-15100674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-15661901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-15696085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-15771580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-1602128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-8766551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-8981913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9151904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9184909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9188449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9498752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9574570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9711780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9784519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16232210-9862675
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
242-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16232210-Allergens,
pubmed-meshheading:16232210-Animals,
pubmed-meshheading:16232210-Antigens, CD80,
pubmed-meshheading:16232210-Antigens, CD86,
pubmed-meshheading:16232210-Aspergillosis, Allergic Bronchopulmonary,
pubmed-meshheading:16232210-Aspergillus fumigatus,
pubmed-meshheading:16232210-Cells, Cultured,
pubmed-meshheading:16232210-Cytokines,
pubmed-meshheading:16232210-Eosinophilia,
pubmed-meshheading:16232210-Female,
pubmed-meshheading:16232210-Immunoglobulin E,
pubmed-meshheading:16232210-Immunoglobulin G,
pubmed-meshheading:16232210-Interleukin-4,
pubmed-meshheading:16232210-Lung,
pubmed-meshheading:16232210-Membrane Glycoproteins,
pubmed-meshheading:16232210-Mice,
pubmed-meshheading:16232210-Mice, Inbred BALB C,
pubmed-meshheading:16232210-Spleen,
pubmed-meshheading:16232210-Tumor Necrosis Factors,
pubmed-meshheading:16232210-Up-Regulation
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pubmed:year |
2005
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