Linked Life Data

16226350

Source:http://linkedlifedata.com/resource/pubmed/id/16226350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-12-6
pubmed:abstractText
Results from basic and clinical studies demonstrate that stress and depression decrease neurotrophic factor expression and neurogenesis in brain, and that antidepressant treatment blocks or reverses these effects, leading to a neurotrophic hypothesis of depression. Neurotrophic factor expression and neurogenesis are also decreased during aging and could be risk factors for depression. In contrast, exercise and enriched environment increase neurotrophic support and neurogenesis, which could contribute to the blockade of the effects of stress and aging and produce antidepressant effects. A brief overview of this work and the specific neurotrophic factors involved are discussed in this review.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
26 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-93
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism.
pubmed:affiliation
Division of Molecular Psychiatry, Departments of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA. ronald.duman@yale.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, N.I.H., Extramural