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rdf:type |
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lifeskim:mentions |
umls-concept:C0013081,
umls-concept:C0017262,
umls-concept:C0042172,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0332281,
umls-concept:C0376358,
umls-concept:C0599851,
umls-concept:C0767524,
umls-concept:C1413800,
umls-concept:C1527440,
umls-concept:C2698947,
umls-concept:C2699128,
umls-concept:C2911684
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|
pubmed:issue |
10
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|
pubmed:dateCreated |
2005-10-17
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|
pubmed:abstractText |
delta-Catenin, or neural plakophilin-related armadillo protein, is a unique armadillo domain-containing protein in that it is neural-specific and primarily expressed in the brain. However, our recent analysis of the human genome revealed a consistent association of delta-catenin messenger RNA sequences with malignant cells, although the significance of these findings was unclear. In this study, we report that a number of delta-catenin epitopes were expressed in human prostate cancer cells. Western blot and tissue microarray revealed a close association between increased delta-catenin expression and human primary prostatic adenocarcinomas. The analyses of 90 human prostate cancer and 90 benign prostate tissue samples demonstrated that an estimated 85% of prostatic adenocarcinomas showed enhanced delta-catenin immunoreactivity. delta-Catenin expression increased with prognostically significant increased Gleason scores. By analyzing the same tumor cell clusters using consecutive sections, we showed that an increased delta-catenin immunoreactivity was accompanied by the down-regulation and redistribution of E-cadherin and p120ctn, major cell junction proteins whose inactivation is frequently associated with cancer progression. Furthermore, overexpression of delta-catenin in tumorigenic CWR-R1 cells that are derived from human prostate cancer xenograft resulted in reduced immunoreactivity for E-cadherin and p120ctn at the cell-cell junction. This is the first study comparing overexpression of delta-catenin with the E-cadherin/catenin system in cancer and shows that delta-catenin may be intimately involved in regulating E-cadherin/p120ctn cell-cell adhesion in prostate cancer progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0046-8177
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1037-48
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16226102-Adenocarcinoma,
pubmed-meshheading:16226102-Animals,
pubmed-meshheading:16226102-Armadillo Domain Proteins,
pubmed-meshheading:16226102-Blotting, Western,
pubmed-meshheading:16226102-Bone Marrow Cells,
pubmed-meshheading:16226102-Cadherins,
pubmed-meshheading:16226102-Catenins,
pubmed-meshheading:16226102-Cell Adhesion Molecules,
pubmed-meshheading:16226102-Cell Line, Tumor,
pubmed-meshheading:16226102-Cells, Cultured,
pubmed-meshheading:16226102-Cytoskeletal Proteins,
pubmed-meshheading:16226102-Down-Regulation,
pubmed-meshheading:16226102-Epithelial Cells,
pubmed-meshheading:16226102-Epitopes,
pubmed-meshheading:16226102-Fluorescent Antibody Technique,
pubmed-meshheading:16226102-Green Fluorescent Proteins,
pubmed-meshheading:16226102-Humans,
pubmed-meshheading:16226102-Immunohistochemistry,
pubmed-meshheading:16226102-Male,
pubmed-meshheading:16226102-Microarray Analysis,
pubmed-meshheading:16226102-PC12 Cells,
pubmed-meshheading:16226102-Phosphoproteins,
pubmed-meshheading:16226102-Precipitin Tests,
pubmed-meshheading:16226102-Prognosis,
pubmed-meshheading:16226102-Prostate,
pubmed-meshheading:16226102-Prostatic Neoplasms,
pubmed-meshheading:16226102-Radioimmunoassay,
pubmed-meshheading:16226102-Rats,
pubmed-meshheading:16226102-Stromal Cells
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pubmed:year |
2005
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|
pubmed:articleTitle |
Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer.
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pubmed:affiliation |
Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA. luq@mail.ecu.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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