Linked Life Data

16225964

Source:http://linkedlifedata.com/resource/pubmed/id/16225964

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-12-6
pubmed:abstractText
The hippocampus is an important integration center for learning and memory in the mammalian central nervous system (CNS) and is particularly sensitive and responsive to changes in insulin and glucose concentrations. Insulin administration improves cognitive performance in a variety of physiological and pathophysiological settings, including diabetes phenotypes. Our previous studies demonstrated that hyperglycemia produces behavioral, neuroanatomical and neurochemical changes in the adult rat hippocampus that are indicative of accelerated brain aging. In addition, the trafficking of insulin-sensitive glucose transporters (GLUTs) is impaired in experimental models of diabetes. Such results suggest that insulin receptor (IR) signaling may be disrupted in diabetes phenotypes, although the signaling mechanisms utilized by neurons are not clearly defined. To this end, we have employed in vivo and in vitro approaches to determine the insulin signaling pathways utilized by neurons. These methodologies provide insight into the signaling mechanisms utilized by neuronal IRs and ultimately will allow for determination of the IR signaling deficits that may contribute to accelerated brain aging in the hippocampus of diabetic subjects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
26 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Neuronal insulin signal transduction mechanisms in diabetes phenotypes.
pubmed:affiliation
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, VA Building 1, Room D40, Columbia, SC 29208, USA. lpreagan@med.sc.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't