Linked Life Data

16225919

Source:http://linkedlifedata.com/resource/pubmed/id/16225919

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-5-29
pubmed:abstractText
The practicality of a probabilistic ecological hazard assessment (PEHA) methodology using intraspecies endpoint sensitivity distributions (IESDs) and chemical toxicity distributions (CTDs) was evaluated on data sets of pharmaceutical toxicity to aquatic macrophytes. A PEHA does not use an exposure distribution but rather uses a point estimate, which is useful for applications with sufficient effects data but lacking in comprehensive exposure data or when a criterion concentration is desired. The probability of finding an effect measure or potency value below a threshold can be calculated from the effects distribution. PEHA analyses using CTDs for both EC(10) and EC(25)Lemna gibba toxicity values indicated a <1% probability of encountering an antibiotic with toxicity below 1 microg/L. IESDs for microcosm mixture studies with eight pharmaceuticals (8PM) and four tetracyclines showed that the probability was nearly 20% for Myriophyllum sibiricum and 13% for L. gibba (8PM data). Hazard quotients calculated from the 1% and 5% distribution thresholds indicated potential risk only in certain cases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0147-6513
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
128-35
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Probabilistic ecological hazard assessment: evaluating pharmaceutical effects on aquatic higher plants as an example.
pubmed:affiliation
Centre for Toxicology and Department of Environmental Biology, University of Guelph, Guelph, Ont., Canada N1G 2W1. rbrain01@uoguelph.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies