rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
|
pubmed:dateCreated |
2006-2-20
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pubmed:abstractText |
We have previously shown that adenoviral-mediated melanoma differentiation-associated gene-7 (Ad.mda-7) therapy induces apoptosis in ovarian cancer cells. However, the apoptosis induction was low and directly correlated with infectivity of Ad.mda-7. The objective of this study was to derive ovarian cancer targeted infectivity-enhanced adenoviral vectors encoding mda-7 and evaluate their enhancement in therapeutic efficacy for ovarian carcinoma.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0090-8258
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pubmed:author |
pubmed-author:AlvarezRonald DRD,
pubmed-author:CareyDeliciaD,
pubmed-author:ChadaSunilS,
pubmed-author:CurielDavid TDT,
pubmed-author:DentPaulP,
pubmed-author:FisherPaul BPB,
pubmed-author:HaismaHidde JHJ,
pubmed-author:KataramManjulaM,
pubmed-author:MahasreshtiParameshwar JPJ,
pubmed-author:WuHongjuH,
pubmed-author:YalavarthyLaxmi PriyaLP
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pubmed:issnType |
Print
|
pubmed:volume |
100
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
521-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16225913-Adenocarcinoma,
pubmed-meshheading:16225913-Adenoviridae,
pubmed-meshheading:16225913-Animals,
pubmed-meshheading:16225913-Cell Line, Tumor,
pubmed-meshheading:16225913-Female,
pubmed-meshheading:16225913-Gene Therapy,
pubmed-meshheading:16225913-Genetic Vectors,
pubmed-meshheading:16225913-Humans,
pubmed-meshheading:16225913-Interleukins,
pubmed-meshheading:16225913-Mice,
pubmed-meshheading:16225913-Mice, SCID,
pubmed-meshheading:16225913-Oligopeptides,
pubmed-meshheading:16225913-Ovarian Neoplasms,
pubmed-meshheading:16225913-Polymerase Chain Reaction,
pubmed-meshheading:16225913-Xenograft Model Antitumor Assays
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pubmed:year |
2006
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pubmed:articleTitle |
Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy.
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pubmed:affiliation |
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA. param@uab.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|