Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-11-30
pubmed:abstractText
Morphogens are developmental regulators that modulate different tissue patterning, proliferation, differentiation, or remodeling processes in embryonic and adult tissues. Morphogens may also evoke specific regulatory programs in stem cells. Some of the morphogens involved in these processes have been characterized, while others remain unidentified. A microarray containing 3,557 salmonid cDNAs was used to compare the transcriptomes of rainbow trout precocious ovary at three different stages during second year (June, August, and October) with a reference (June normal ovary) transcriptome. During this study, we detected morphogen transcript hybridizations to salmonid elements and the study was enlarged to investigate these activities in various developmental stages of both ovary and testis. Genes from diverse development regulator families such as Anterior gradient-2, BMP, Epimorphin, Flightless, Frizzled, Notch, Tiarin, Twisted gastrulation, and Wnt were demonstrated to be expressed in the adult trout gonads. In mice or rats, expression of mammalian bmp-4, epimorphin, flightless, twisted gastrulation, and GW112 transcripts were localized to cell types isolated from the developed ovary and testis. Comparisons of salmonid and mammalian morphogens at the amino acid residue level show high similarities, suggesting functional conservation. This report provides evidence for local regulation by various morphogens and their potential to control distinct programs of gene expression in the gametes and their accessory cells during gametogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1040-452X
pubmed:author
pubmed:copyrightInfo
(c) 2005 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
142-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16224774-Amino Acid Sequence, pubmed-meshheading:16224774-Animals, pubmed-meshheading:16224774-Body Patterning, pubmed-meshheading:16224774-Cell Lineage, pubmed-meshheading:16224774-Female, pubmed-meshheading:16224774-Gene Expression Regulation, Developmental, pubmed-meshheading:16224774-Humans, pubmed-meshheading:16224774-Male, pubmed-meshheading:16224774-Mice, pubmed-meshheading:16224774-Mice, Inbred C57BL, pubmed-meshheading:16224774-Molecular Sequence Data, pubmed-meshheading:16224774-Morphogenesis, pubmed-meshheading:16224774-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:16224774-Oncorhynchus mykiss, pubmed-meshheading:16224774-Ovary, pubmed-meshheading:16224774-Rats, pubmed-meshheading:16224774-Seasons, pubmed-meshheading:16224774-Sequence Alignment, pubmed-meshheading:16224774-Stem Cells, pubmed-meshheading:16224774-Testis, pubmed-meshheading:16224774-Xenopus
pubmed:year
2006
pubmed:articleTitle
Expression of morphogenic genes in mature ovarian and testicular tissues: potential stem-cell niche markers and patterning factors.
pubmed:affiliation
Centre for Biomedical Research, University of Victoria, Victoria, British Columbia, Canada.
pubmed:publicationType
Journal Article, Comparative Study