Source:http://linkedlifedata.com/resource/pubmed/id/16223474
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
2006-2-6
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pubmed:abstractText |
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Several mutations in the TPMT gene have been identified which correlate with a low activity phenotype. The molecular basis for TPMT deficiency is not well defined in minority Chinese. We investigated differences in the activity of TPMT and the frequencies of mutant TPMT alleles in 4 ethnic groups of Chinese.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-8981
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
365
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16223474-Adult,
pubmed-meshheading:16223474-Alleles,
pubmed-meshheading:16223474-Base Sequence,
pubmed-meshheading:16223474-China,
pubmed-meshheading:16223474-DNA Primers,
pubmed-meshheading:16223474-Ethnic Groups,
pubmed-meshheading:16223474-Female,
pubmed-meshheading:16223474-Humans,
pubmed-meshheading:16223474-Male,
pubmed-meshheading:16223474-Methyltransferases,
pubmed-meshheading:16223474-Polymerase Chain Reaction,
pubmed-meshheading:16223474-Polymorphism, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
Determination of intra-ethnic differences in the polymorphisms of thiopurine S-methyltransferase in Chinese.
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pubmed:affiliation |
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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