|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0012854,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0020971,
umls-concept:C0026809,
umls-concept:C0056912,
umls-concept:C0442821,
umls-concept:C0681205,
umls-concept:C0871261,
umls-concept:C1550555,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2006-2-14
|
|
pubmed:abstractText |
HIV-1 Immunogen is a gp120-depleted whole killed virus vaccine candidate formulated with Incomplete Freund's Adjuvant (HIV-IFA). We evaluated in a mouse model the immunogenicity of HIV-IFA by itself and when combined with HYB2055, an immunomodulatory oligonucleotide consisting of a novel DNA structure and synthetic CpR immunostimulatory motif, as an adjuvant. C57/BL6 mice were immunized with HIV-IFA alone or combined with HYB2055. Mice treated with HYB2055 or with PBS were used as controls. Compared to HIV-IFA alone, immunization with HIV-IFA and HYB2055 combination elicited strong production of HIV- and p24-specific IFNgamma, RANTES, MIP 1alpha, and MIP 1beta, as well as high titers of HIV- and p24-specific antibodies. Inclusion of HYB2055 also reduced levels of IL-5 produced by HIV-IFA alone. HYB2055 enhances the immunogenicity of HIV-IFA and shifts responses towards a type 1 cytokine profile. The immune enhancing effects of HYB2055 adjuvant were dose-dependent. These findings warrant clinical evaluation of the HIV-1 immunogen/HYB2055 candidate as a therapeutic vaccine for HIV-1 infected patients.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AIDS Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL3,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/HIV-1 immunogen, incomplete...,
http://linkedlifedata.com/resource/pubmed/chemical/HYB-2055,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0264-410X
|
|
pubmed:author |
pubmed-author:AgrawalSudhirS,
pubmed-author:BartholomewRichardR,
pubmed-author:BeltramiSilviaS,
pubmed-author:BhagatLakshmiL,
pubmed-author:BrayDorothy HDH,
pubmed-author:CesanaEugenioE,
pubmed-author:ClericiMarioM,
pubmed-author:ClivioAlbertoA,
pubmed-author:KandimallaEkambar RER,
pubmed-author:LissoniFrancescaF,
pubmed-author:LowryPeterP,
pubmed-author:MaffeisGiadaG,
pubmed-author:SullivanTimothyT,
pubmed-author:TrabattoniDariaD
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1470-7
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:16221513-AIDS Vaccines,
pubmed-meshheading:16221513-Animals,
pubmed-meshheading:16221513-Cells, Cultured,
pubmed-meshheading:16221513-Chemokine CCL3,
pubmed-meshheading:16221513-Chemokine CCL4,
pubmed-meshheading:16221513-Chemokine CCL5,
pubmed-meshheading:16221513-Cytokines,
pubmed-meshheading:16221513-Drug Therapy, Combination,
pubmed-meshheading:16221513-Female,
pubmed-meshheading:16221513-HIV Antibodies,
pubmed-meshheading:16221513-HIV Envelope Protein gp120,
pubmed-meshheading:16221513-Interferon-gamma,
pubmed-meshheading:16221513-Interleukin-5,
pubmed-meshheading:16221513-Lymphocytes,
pubmed-meshheading:16221513-Macrophage Inflammatory Proteins,
pubmed-meshheading:16221513-Mice,
pubmed-meshheading:16221513-Mice, Inbred C57BL,
pubmed-meshheading:16221513-Oligonucleotides
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice.
|
|
pubmed:affiliation |
Chair of Immunology, DISP LITA Vialba, Via GB Grassi 74, 20157 Milano, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
