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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-8-5
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pubmed:abstractText |
Eight patients received either recombinant Interleukin-2 (rIL-2) alone or rIL-2 plus 5-Fluorouracil (5-FU) by constant infusion after undergoing potentially curative surgery for gastric cancer. rIL-2, given at a dose of 18 x 10(6) IU/m2/24 hours, was safely tolerated and only two episodes of WHO grade 3 toxicities occurred, both of which promptly responded to treatment and temporary interruptions of rIL-2 infusions. 5-FU infusions given at 12.5 mg/kg/24 hours did not alter the rebound lymphocytosis seen after completion of rIL-2 infusions. We conclude that the administration of rIL-2 and rIL-2 plus 5-FU to cancer patients recovering from major surgery is safe and well tolerated.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
749-52
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1622133-Aged,
pubmed-meshheading:1622133-Feasibility Studies,
pubmed-meshheading:1622133-Female,
pubmed-meshheading:1622133-Fluorouracil,
pubmed-meshheading:1622133-Humans,
pubmed-meshheading:1622133-Interleukin-2,
pubmed-meshheading:1622133-Leukocyte Count,
pubmed-meshheading:1622133-Lymphocytes,
pubmed-meshheading:1622133-Male,
pubmed-meshheading:1622133-Neoplasm Staging,
pubmed-meshheading:1622133-Pilot Projects,
pubmed-meshheading:1622133-Recombinant Proteins,
pubmed-meshheading:1622133-Stomach Neoplasms
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pubmed:articleTitle |
Evaluation of the safety of recombinant interleukin-2 (rIL-2) and rIL-2 plus 5-fluorouracil (5-FU) in the adjuvant treatment of gastric cancer patients.
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pubmed:affiliation |
Department of Surgery, General Hospital, Leicester, U.K.
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pubmed:publicationType |
Journal Article
|