Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-10-13
pubmed:abstractText
The immunosuppressive (IS) regimen based on sirolimus/low-dose tacrolimus is considered a major determinant of success of the Edmonton protocol. This regimen is generally considered safe or even protective for the kidney. Herein, we analyzed the impact of the sirolimus/low-dose tacrolimus combination on kidney function. The medical charts of islet transplant recipients with at least 6 months follow up were reviewed. There were five islet-after-kidney and five islet transplantation alone patients. Serum creatinin, albuminuria, metabolic control markers and graft function were analyzed. Impairment of kidney function was observed in six of 10 patients. Neither metabolic markers nor IS drugs levels were significantly associated with the decrease of kidney function. Although a specific etiology was not identified, some subsets of patients presented a higher risk for decline of kidney function. Low creatinin clearance, albuminuria and long-established kidney graft were associated with poorer outcome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0934-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1226-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16221151-Adult, pubmed-meshheading:16221151-Biopsy, pubmed-meshheading:16221151-Creatinine, pubmed-meshheading:16221151-Delayed Graft Function, pubmed-meshheading:16221151-Diabetes Mellitus, Type 1, pubmed-meshheading:16221151-Drug Therapy, Combination, pubmed-meshheading:16221151-Female, pubmed-meshheading:16221151-Follow-Up Studies, pubmed-meshheading:16221151-Graft Rejection, pubmed-meshheading:16221151-Humans, pubmed-meshheading:16221151-Immunosuppressive Agents, pubmed-meshheading:16221151-Islets of Langerhans Transplantation, pubmed-meshheading:16221151-Kidney Transplantation, pubmed-meshheading:16221151-Male, pubmed-meshheading:16221151-Middle Aged, pubmed-meshheading:16221151-Retrospective Studies, pubmed-meshheading:16221151-Sirolimus, pubmed-meshheading:16221151-Tacrolimus
pubmed:year
2005
pubmed:articleTitle
Impairment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen.
pubmed:affiliation
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't