| pubmed-article:16219031 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0205095 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0504074 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0164209 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0206128 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0178702 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C1424685 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:16219031 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:16219031 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:16219031 | pubmed:dateCreated | 2005-12-20 | lld:pubmed |
| pubmed-article:16219031 | pubmed:abstractText | Antagonists at NK1 substance P receptors have demonstrated similar antidepressant properties in both animal paradigms and in human as selective serotonin reuptake inhibitors (SSRIs) that induce desensitization of 5-HT 1A autoreceptors within the dorsal raphe nucleus (DRN). We investigated whether this receptor adaptation also occurs upon NK1 receptor blockade. C57B/L6J mice were treated for 21 days with the selective NK1 receptor antagonist GR 205171 (10 mg/kg daily) through subcutaneously implanted osmotic mini pumps, and DRN 5-HT 1A autoreceptor functioning was assessed using various approaches. Recording of DRN serotonergic neurons in brainstem slices showed that GR 205171 treatment reduced (by approximately 1.5 fold) the potency of the 5-HT 1A receptor agonist, ipsapirone, to inhibit cell firing. In parallel, the 5-HT 1A autoreceptor-mediated [35S]GTP-gamma-S binding induced by 5-carboxamidotryptamine onto the DRN in brainstem sections was significantly decreased in GR 205171-treated mice. In vivo microdialysis showed that the cortical 5-HT overflow caused by acute injection of the SSRI paroxetine (1 mg/kg) was twice as high in GR 205171-treated as in vehicle-treated controls. In the DRN, basal 5-HT outflow was significantly enhanced by GR 205171 treatment. These data supported the hypothesis that chronic NK1 receptor blockade induces a functional desensitization of 5-HT 1A autoreceptors similar to that observed with SSRIs. | lld:pubmed |
| pubmed-article:16219031 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16219031 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16219031 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16219031 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:16219031 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:16219031 | pubmed:author | pubmed-author:HamonMichelM | lld:pubmed |
| pubmed-article:16219031 | pubmed:author | pubmed-author:LanfumeyLaure... | lld:pubmed |
| pubmed-article:16219031 | pubmed:author | pubmed-author:GardierAlain... | lld:pubmed |
| pubmed-article:16219031 | pubmed:author | pubmed-author:FrogerNicolas... | lld:pubmed |
| pubmed-article:16219031 | pubmed:author | pubmed-author:GuiardBruno... | lld:pubmed |
| pubmed-article:16219031 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16219031 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:16219031 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16219031 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16219031 | pubmed:pagination | 1713-23 | lld:pubmed |
| pubmed-article:16219031 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:meshHeading | pubmed-meshheading:16219031... | lld:pubmed |
| pubmed-article:16219031 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16219031 | pubmed:articleTitle | Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice. | lld:pubmed |
| pubmed-article:16219031 | pubmed:affiliation | INSERM/UPMC, Neuropsychopharmacologie, CHU Pitié-Salpêtrière, Paris, France. | lld:pubmed |
| pubmed-article:16219031 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16219031 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
