16218807

Source:http://linkedlifedata.com/resource/pubmed/id/16218807

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019682, umls-concept:C0019699, umls-concept:C0021311, umls-concept:C0030705, umls-concept:C0162326, umls-concept:C0209150, umls-concept:C0332293, umls-concept:C0332307, umls-concept:C0439662, umls-concept:C0450442, umls-concept:C0936012, umls-concept:C1301820
pubmed:issue	9
pubmed:dateCreated	2005-10-12
pubmed:databankReference	http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451359, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451360, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451361, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451362, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451363, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451364, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451365, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451366, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451367, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451368, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451369, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451370, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451371, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451372, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451373, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451374, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451375, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451376, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451377, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451378, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451379, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451380, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451381, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451382, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451383, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451384, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451385, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451386, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451387, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451388, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451389, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451390, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451391, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451392, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451393, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF451394
pubmed:abstractText	Tucaresol, a Schiff base-forming compound that is shown to enhance cytotoxic T cell responses and the production of type 1 cytokines, represents a potentially useful adjuvant factor for treating HIV-1 infection. We studied the effect of tucaresol on V3 sequences within the HIV-1 env region derived from patients with different virologic and immunologic features who were enrolled in a phase I/II randomized clinical trial. The sequence analysis of the env V3 region of the viruses at baseline has confirmed a genotypic pattern similar to a macrophagotropic virus model; we analyzed the follow-up sequences at week 16 of the protocol and did not observe any difference in the tropism determinants within the third variable fragment of the env region. The administration of tucaresol did not accelerate env V3 evolution thus preventing modifications of HIV-1 tropism over time.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8709376
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Benzaldehydes, http://linkedlifedata.com/resource/pubmed/chemical/Benzoates, http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120, http://linkedlifedata.com/resource/pubmed/chemical/HIV envelope protein gp120 (305-321), http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors, http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments, http://linkedlifedata.com/resource/pubmed/chemical/tucaresol
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0889-2229
pubmed:author	pubmed-author:BanderaAlessandraA, pubmed-author:BulgheroniElisabettaE, pubmed-author:GalliMassimoM, pubmed-author:GoriAndreaA, pubmed-author:RusconiStefanoS
pubmed:issnType	Print
pubmed:volume	21
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	815-9
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16218807-Amino Acid Sequence, pubmed-meshheading:16218807-Benzaldehydes, pubmed-meshheading:16218807-Benzoates, pubmed-meshheading:16218807-HIV Envelope Protein gp120, pubmed-meshheading:16218807-HIV Infections, pubmed-meshheading:16218807-HIV-1, pubmed-meshheading:16218807-Humans, pubmed-meshheading:16218807-Immunologic Factors, pubmed-meshheading:16218807-Molecular Sequence Data, pubmed-meshheading:16218807-Peptide Fragments, pubmed-meshheading:16218807-Sequence Alignment, pubmed-meshheading:16218807-Time Factors, pubmed-meshheading:16218807-Treatment Outcome
pubmed:year	2005
pubmed:articleTitle	Analysis of the env V3 sequences obtained from patients with HIV type 1 infection treated with the immune modulant agent tucaresol.
pubmed:affiliation	Institute of Infectious and Tropical Diseases, University of Milan, Ospedale Luigi Sacco, 20157 Milan, Italy.
pubmed:publicationType	Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't, Clinical Trial, Phase II, Clinical Trial, Phase I