| pubmed-article:16217143 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C0002903 | lld:lifeskim |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C0018549 | lld:lifeskim |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C0041964 | lld:lifeskim |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:16217143 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:16217143 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16217143 | pubmed:dateCreated | 2005-10-18 | lld:pubmed |
| pubmed-article:16217143 | pubmed:abstractText | Potential utility of halothane-anesthetized guinea pigs for detecting drug-induced repolarization delay was analyzed in comparison with urethane-anesthesia (n = 4 for both groups). Basal QT interval was significantly greater under halothane-anesthesia than urethane-anesthesia (192 +/- 7 vs 132 +/- 5 ms, respectively), whereas the reverse was true for the heart rate (190 +/- 7 vs 248 +/- 11 beats/min, respectively). The typical I(Kr)-blocker dl-sotalol (0.1 to 3 mg/kg, i.v.) induced dose-related bradycardia and QT interval prolongation under each anesthesia. The extent of maximum prolongation in the QT interval was greater under halothane-anesthesia than urethane-anesthesia (+101 +/- 15 vs +49 +/- 3 ms, respectively), whereas that of peak change in the heart rate was smaller under the former than the latter (-49 +/- 8 vs -63 +/- 5 beats/min, respectively). Pretreatment of the animals under urethane-anesthesia with the selective I(Ks) blocker chromanol 293B (n = 6) increased the extent of the dl-sotalol-induced QT interval prolongation to +57 +/- 8 ms, which was only 0.56 times of that under the halothane-anesthesia, whereas the pretreatment increased the peak change in the heart rate to -76 +/- 12 ms. These results indicate that the halothane-anesthesia may effectively sensitize the guinea-pig heart to pharmacological I(Kr) blockade. | lld:pubmed |
| pubmed-article:16217143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16217143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16217143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16217143 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16217143 | pubmed:issn | 1347-8613 | lld:pubmed |
| pubmed-article:16217143 | pubmed:author | pubmed-author:HashimotoKeit... | lld:pubmed |
| pubmed-article:16217143 | pubmed:author | pubmed-author:TakaharaAkira... | lld:pubmed |
| pubmed-article:16217143 | pubmed:author | pubmed-author:SugiyamaAtsus... | lld:pubmed |
| pubmed-article:16217143 | pubmed:author | pubmed-author:AkieYasukiY | lld:pubmed |
| pubmed-article:16217143 | pubmed:author | pubmed-author:SakaguchiYasu... | lld:pubmed |
| pubmed-article:16217143 | pubmed:author | pubmed-author:TakaoShujiS | lld:pubmed |
| pubmed-article:16217143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16217143 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:16217143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16217143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16217143 | pubmed:pagination | 185-90 | lld:pubmed |
| pubmed-article:16217143 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16217143 | pubmed:meshHeading | pubmed-meshheading:16217143... | lld:pubmed |
| pubmed-article:16217143 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16217143 | pubmed:articleTitle | Halothane sensitizes the guinea-pig heart to pharmacological IKr blockade: comparison with urethane anesthesia. | lld:pubmed |
| pubmed-article:16217143 | pubmed:affiliation | Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan. | lld:pubmed |
| pubmed-article:16217143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16217143 | pubmed:publicationType | Comparative Study | lld:pubmed |
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