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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-10-18
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pubmed:abstractText |
Potential utility of halothane-anesthetized guinea pigs for detecting drug-induced repolarization delay was analyzed in comparison with urethane-anesthesia (n = 4 for both groups). Basal QT interval was significantly greater under halothane-anesthesia than urethane-anesthesia (192 +/- 7 vs 132 +/- 5 ms, respectively), whereas the reverse was true for the heart rate (190 +/- 7 vs 248 +/- 11 beats/min, respectively). The typical I(Kr)-blocker dl-sotalol (0.1 to 3 mg/kg, i.v.) induced dose-related bradycardia and QT interval prolongation under each anesthesia. The extent of maximum prolongation in the QT interval was greater under halothane-anesthesia than urethane-anesthesia (+101 +/- 15 vs +49 +/- 3 ms, respectively), whereas that of peak change in the heart rate was smaller under the former than the latter (-49 +/- 8 vs -63 +/- 5 beats/min, respectively). Pretreatment of the animals under urethane-anesthesia with the selective I(Ks) blocker chromanol 293B (n = 6) increased the extent of the dl-sotalol-induced QT interval prolongation to +57 +/- 8 ms, which was only 0.56 times of that under the halothane-anesthesia, whereas the pretreatment increased the peak change in the heart rate to -76 +/- 12 ms. These results indicate that the halothane-anesthesia may effectively sensitize the guinea-pig heart to pharmacological I(Kr) blockade.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-cyano-4-(N-ethylsulfonyl-N-methyla...,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Intravenous,
http://linkedlifedata.com/resource/pubmed/chemical/Chromans,
http://linkedlifedata.com/resource/pubmed/chemical/Delayed Rectifier Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Halothane,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Sotalol,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Urethane
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1347-8613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16217143-Action Potentials,
pubmed-meshheading:16217143-Anesthetics, Inhalation,
pubmed-meshheading:16217143-Anesthetics, Intravenous,
pubmed-meshheading:16217143-Animals,
pubmed-meshheading:16217143-Chromans,
pubmed-meshheading:16217143-Delayed Rectifier Potassium Channels,
pubmed-meshheading:16217143-Drug Evaluation, Preclinical,
pubmed-meshheading:16217143-Electrocardiography,
pubmed-meshheading:16217143-Guinea Pigs,
pubmed-meshheading:16217143-Halothane,
pubmed-meshheading:16217143-Heart Rate,
pubmed-meshheading:16217143-Male,
pubmed-meshheading:16217143-Potassium,
pubmed-meshheading:16217143-Potassium Channel Blockers,
pubmed-meshheading:16217143-Sotalol,
pubmed-meshheading:16217143-Sulfonamides,
pubmed-meshheading:16217143-Time Factors,
pubmed-meshheading:16217143-Urethane
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pubmed:year |
2005
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pubmed:articleTitle |
Halothane sensitizes the guinea-pig heart to pharmacological IKr blockade: comparison with urethane anesthesia.
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pubmed:affiliation |
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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