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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2005-11-7
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pubmed:abstractText |
Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:DiGrandiMartin JMJ,
pubmed-author:DuXuemeiX,
pubmed-author:FuY PYP,
pubmed-author:HuYonghanY,
pubmed-author:IpekManusM,
pubmed-author:LaaksoLeif MLM,
pubmed-author:LevinJeremy IJI,
pubmed-author:LiJianchangJ,
pubmed-author:RushThomas STS,
pubmed-author:SchmidJeanJ,
pubmed-author:SkotnickiJerauld SJS,
pubmed-author:StentV CVC,
pubmed-author:ThomasonJennifer RJR,
pubmed-author:WangQinQ,
pubmed-author:XiangJason SJS
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6629-44
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16216515-Administration, Oral,
pubmed-meshheading:16216515-Animals,
pubmed-meshheading:16216515-Benzofurans,
pubmed-meshheading:16216515-Collagenases,
pubmed-meshheading:16216515-Drug Evaluation, Preclinical,
pubmed-meshheading:16216515-Enzyme Inhibitors,
pubmed-meshheading:16216515-Inhibitory Concentration 50,
pubmed-meshheading:16216515-Matrix Metalloproteinase 13,
pubmed-meshheading:16216515-Models, Molecular,
pubmed-meshheading:16216515-Molecular Structure,
pubmed-meshheading:16216515-Osteoarthritis,
pubmed-meshheading:16216515-Rats,
pubmed-meshheading:16216515-Substrate Specificity
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pubmed:year |
2005
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pubmed:articleTitle |
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
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pubmed:affiliation |
Department of Chemical and Screening Sciences, Wyeth Research, Cambridge, MA 02140, USA. fhu@wyeth.com
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pubmed:publicationType |
Journal Article
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