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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2005-11-1
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pubmed:abstractText |
Two novel 8,6-fused bicyclic peptidomimetic ring systems were synthesized utilizing olefin metathesis as the key reaction for the formation of the eight-membered ring. Both peptidomimetic scaffolds were further elaborated into potent ICE inhibitors, with numerous compounds exhibiting caspase-1 IC(50)s less than 10nM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BaizeMark WMW,
pubmed-author:BoschGregory KGK,
pubmed-author:DeBiswanathB,
pubmed-author:DemuthThomas PTPJr,
pubmed-author:EllisChristopher DCD,
pubmed-author:FancherAmy NAN,
pubmed-author:LaufersweilerMichael CMC,
pubmed-author:O'NeilSteven VSV,
pubmed-author:OppongKofi AKA,
pubmed-author:SoperDavid LDL,
pubmed-author:SuchanekMaureen KMK,
pubmed-author:WangRichard LRL,
pubmed-author:WangYiliY,
pubmed-author:WosJohn AJA,
pubmed-author:YenPP
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
5434-8
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pubmed:meshHeading |
|
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.
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pubmed:affiliation |
Procter & Gamble Pharmaceuticals, Inc., 8700 Mason-Montgomery Road, Mason, OH 45040, USA. oneil.sv@pg.com
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pubmed:publicationType |
Journal Article
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