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16216502
Source:
http://linkedlifedata.com/resource/pubmed/id/16216502
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Statements in which the resource exists as a subject.
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0205460
,
umls-concept:C0220781
,
umls-concept:C0220825
,
umls-concept:C1152564
,
umls-concept:C1521827
,
umls-concept:C1704322
,
umls-concept:C1707689
,
umls-concept:C1883254
pubmed:issue
1
pubmed:dateCreated
2005-11-18
pubmed:abstractText
We report the synthesis of kinase targeted libraries based on the thienopyrazole scaffold. Several thienopyrazole analogs have been identified as submicromolar inhibitors of KDR.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles
,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0960-894X
pubmed:author
pubmed-author:Akritopoulou-ZanzeIriniI
,
pubmed-author:DarczakDariaD
,
pubmed-author:DjuricStevan WSW
,
pubmed-author:HuthJeffrey RJR
,
pubmed-author:JiaYongY
,
pubmed-author:JohnsonEric FEF
,
pubmed-author:PhelanKathleen MKM
,
pubmed-author:SarrisKathyK
,
pubmed-author:SongDanyingD
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16216502-Chemistry, Pharmaceutical
,
pubmed-meshheading:16216502-Drug Design
,
pubmed-meshheading:16216502-Drug Evaluation, Preclinical
,
pubmed-meshheading:16216502-Enzyme Inhibitors
,
pubmed-meshheading:16216502-Humans
,
pubmed-meshheading:16216502-Inhibitory Concentration 50
,
pubmed-meshheading:16216502-Models, Chemical
,
pubmed-meshheading:16216502-Phosphotransferases
,
pubmed-meshheading:16216502-Pyrazoles
,
pubmed-meshheading:16216502-Vascular Endothelial Growth Factor Receptor-2
pubmed:year
2006
pubmed:articleTitle
Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors.
pubmed:affiliation
Abbott, 100 Abbott Park Road, Abbott Park, IL 60044, USA. irini.zanze@abbott.com
pubmed:publicationType
Journal Article