16216497

Source:http://linkedlifedata.com/resource/pubmed/id/16216497

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0035015, umls-concept:C0178784, umls-concept:C0205177, umls-concept:C0205531, umls-concept:C0226896, umls-concept:C0442027, umls-concept:C0450127, umls-concept:C1292733, umls-concept:C1527415, umls-concept:C1548437, umls-concept:C1623395, umls-concept:C1880355, umls-concept:C1882923, umls-concept:C1999216
pubmed:issue	1
pubmed:dateCreated	2005-11-18
pubmed:abstractText	We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/1-methyl-1H-indole-2-carboxylic..., http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein..., http://linkedlifedata.com/resource/pubmed/chemical/Pharmaceutical Preparations, http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles, http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines, http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0960-894X
pubmed:author	pubmed-author:BorhaniDavid WDW, pubmed-author:BurchatAndrewA, pubmed-author:CalderwoodDavid JDJ, pubmed-author:HirstGavin CGC, pubmed-author:LiBiqinB, pubmed-author:StachlewitzRobert FRF
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	118-22
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:16216497-Animals, pubmed-meshheading:16216497-Chemistry, Pharmaceutical, pubmed-meshheading:16216497-Crystallography, X-Ray, pubmed-meshheading:16216497-Drug Design, pubmed-meshheading:16216497-Enzyme Inhibitors, pubmed-meshheading:16216497-Graft Rejection, pubmed-meshheading:16216497-Heart Transplantation, pubmed-meshheading:16216497-Humans, pubmed-meshheading:16216497-Immunophenotyping, pubmed-meshheading:16216497-Immunosuppressive Agents, pubmed-meshheading:16216497-Inhibitory Concentration 50, pubmed-meshheading:16216497-Kinetics, pubmed-meshheading:16216497-Lymphocyte Specific Protein Tyrosine Kinase p56(lck), pubmed-meshheading:16216497-Major Histocompatibility Complex, pubmed-meshheading:16216497-Models, Chemical, pubmed-meshheading:16216497-Models, Molecular, pubmed-meshheading:16216497-Pharmaceutical Preparations, pubmed-meshheading:16216497-Pyrazoles, pubmed-meshheading:16216497-Pyrimidines, pubmed-meshheading:16216497-Rats, pubmed-meshheading:16216497-Time Factors, pubmed-meshheading:16216497-Transplantation, Homologous, pubmed-meshheading:16216497-src-Family Kinases
pubmed:year	2006
pubmed:articleTitle	Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
pubmed:affiliation	Abbott Bioresearch Center, 100 Research Drive, Worcester, MA 01605-5314, USA.
pubmed:publicationType	Journal Article