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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2005-11-1
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pubmed:abstractText |
The selective antagonist radioligand [(3)H]2-propylthioadenosine-5'-adenylic acid (1,1-dichloro-1-phosphonomethyl-1-phosphonyl) anhydride ([(3)H]PSB-0413) was prepared by catalytic hydrogenation of its propargyl precursor with a high specific radioactivity of 74Ci/mmol. In preliminary saturation binding studies, [(3)H]PSB-0413 showed high affinity for platelet P2Y(12) receptors with a K(D) value of 4.57nM. Human platelets had a high density of P2Y(12) receptors exhibiting a B(max) value of 7.66pmol/mg of protein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5450-2
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16213725-Adenosine Monophosphate,
pubmed-meshheading:16213725-Blood Platelets,
pubmed-meshheading:16213725-Humans,
pubmed-meshheading:16213725-Kinetics,
pubmed-meshheading:16213725-Purinergic P2 Receptor Antagonists,
pubmed-meshheading:16213725-Radioligand Assay,
pubmed-meshheading:16213725-Receptors, Purinergic P2,
pubmed-meshheading:16213725-Receptors, Purinergic P2Y12,
pubmed-meshheading:16213725-Thionucleosides,
pubmed-meshheading:16213725-Tritium
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors.
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pubmed:affiliation |
Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), University of Bonn, Kreuzbergweg 26, D-53115 Bonn, Germany.
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pubmed:publicationType |
Journal Article
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