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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2005-10-10
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pubmed:abstractText |
The adipocyte has pleiotropic functions beyond the storage of energy in times of nutrient abundance. Considerable efforts in adipocyte biology within the past ten years have emphasized the important role of adipose tissue in processes as diverse as energy metabolism, inflammation and cancer. Adipocytes are able to communicate with the brain and peripheral tissues implementing metabolic signals such as satiety, food intake and energy expenditure. Despite its huge pharmacological potential, only a small number of clinical applications interfere directly with adipocyte physiology. Here, we want to highlight various areas of adipocyte physiology that have not yet been explored pharmacologically and emphasize some of the limitations associated with these pharmacotherapies.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
|
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pubmed:issn |
1359-6446
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
10
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1219-30
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16213414-Adipocytes,
pubmed-meshheading:16213414-Adiponectin,
pubmed-meshheading:16213414-Animals,
pubmed-meshheading:16213414-Apoptosis,
pubmed-meshheading:16213414-Cell Differentiation,
pubmed-meshheading:16213414-Drug Design,
pubmed-meshheading:16213414-Hormones, Ectopic,
pubmed-meshheading:16213414-Humans,
pubmed-meshheading:16213414-Inflammation,
pubmed-meshheading:16213414-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:16213414-Leptin,
pubmed-meshheading:16213414-Lipid Metabolism,
pubmed-meshheading:16213414-Reactive Oxygen Species,
pubmed-meshheading:16213414-Resistin
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pubmed:year |
2005
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|
pubmed:articleTitle |
Keynote review: the adipocyte as a drug discovery target.
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pubmed:affiliation |
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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