Source:http://linkedlifedata.com/resource/pubmed/id/16213273
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2005-10-10
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| pubmed:abstractText |
We retrospectively evaluated the long-term results of 53 (3.5%) recipients who received second allograft among 1486 kidney transplants between November 3, 1975 and June 30, 2004. Two study groups were patients in Group 1 (n = 21) who underwent allograft nephrectomy and those in Group 2 (n = 32) who did not. We assessed demographic features, rejection rates throughout the follow-up period, and serum creatinine levels at 12 months as well as graft and patient survival rates, postoperative complications, time interval between transplantations, and HLA matches. Forty-three patients who underwent retransplantation received kidneys from living-related donors and the remaining 10 from cadaveric donors. Mean serum creatinine levels of Group 1 versus Group 2 were 1.8 mg/dL (range, 0.8 to 6.6 mg/dL) versus 2.1 +/- 1.1 mg/dL (range, 1.1 to 7.1 mg/dL). HLA-AB and HLA-DR mismatches were 1.9 +/- 1.1 versus 1 +/- 0.6, respectively (P = .01). Acute rejection rates were not significantly different between Groups 1 (9/21, 43%) and 2 (12/32, 38%) (P < .05). The average intervals between the first and the second transplantations were 62 +/- 26 months in Group 1 (P = .02) and 32 +/- 11 months in Group 2. One-, 3-, and 5-year graft survival rates in Group 1 versus Group 2 were 83% versus 89% (P > .05); 64% versus 79% (P > .05), and 45% versus 68% (P = .04), respectively. In conclusion, we did not observe any advantage of graft nephrectomy before retransplantation. The length of the interval between the first and the second transplantations may have a negative correlation with second graft survival.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0041-1345
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
37
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2957-61
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| pubmed:meshHeading |
pubmed-meshheading:16213273-Adolescent,
pubmed-meshheading:16213273-Adult,
pubmed-meshheading:16213273-Age Distribution,
pubmed-meshheading:16213273-Cadaver,
pubmed-meshheading:16213273-Creatinine,
pubmed-meshheading:16213273-Graft Rejection,
pubmed-meshheading:16213273-Graft Survival,
pubmed-meshheading:16213273-Histocompatibility Testing,
pubmed-meshheading:16213273-Humans,
pubmed-meshheading:16213273-Kidney Transplantation,
pubmed-meshheading:16213273-Living Donors,
pubmed-meshheading:16213273-Middle Aged,
pubmed-meshheading:16213273-Nephrectomy,
pubmed-meshheading:16213273-Reoperation,
pubmed-meshheading:16213273-Retrospective Studies,
pubmed-meshheading:16213273-Survival Analysis,
pubmed-meshheading:16213273-Tissue Donors,
pubmed-meshheading:16213273-Transplantation, Homologous
|
| pubmed:year |
2005
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| pubmed:articleTitle |
The effect of graft nephrectomy on long-term graft function and survival in kidney retransplantation.
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| pubmed:affiliation |
Baskent University Faculty of Medicine, Department of General Surgery Division of Transplantation, Ankara Turkey.
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| pubmed:publicationType |
Journal Article
|