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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2005-10-19
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pubmed:abstractText |
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AckermannJeanJ,
pubmed-author:AligLeoL,
pubmed-author:BöhmHans-JoachimHJ,
pubmed-author:BannerDavid WDW,
pubmed-author:HilpertKurtK,
pubmed-author:KühneHolgerH,
pubmed-author:LavéThierryT,
pubmed-author:Obst-SanderUlrikeU,
pubmed-author:RiedererMarkus AMA,
pubmed-author:StahlMartinM,
pubmed-author:TschoppThomas BTB,
pubmed-author:WeberLutzL,
pubmed-author:WesselHans PeterHP,
pubmed-author:ZbindenKatrin GroebkeKG
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5344-52
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pubmed:meshHeading |
pubmed-meshheading:16213138-Administration, Oral,
pubmed-meshheading:16213138-Animals,
pubmed-meshheading:16213138-Anticoagulants,
pubmed-meshheading:16213138-Biological Availability,
pubmed-meshheading:16213138-Crystallography, X-Ray,
pubmed-meshheading:16213138-Drug Design,
pubmed-meshheading:16213138-Factor VIIa,
pubmed-meshheading:16213138-Glycine,
pubmed-meshheading:16213138-Humans,
pubmed-meshheading:16213138-Molecular Structure,
pubmed-meshheading:16213138-Rats,
pubmed-meshheading:16213138-Serine Proteinase Inhibitors,
pubmed-meshheading:16213138-Thromboplastin
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pubmed:year |
2005
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pubmed:articleTitle |
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
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pubmed:affiliation |
F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland. katrin.groebke_zbinden@roche.com
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pubmed:publicationType |
Journal Article
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