Source:http://linkedlifedata.com/resource/pubmed/id/16212632
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2005-10-10
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| pubmed:abstractText |
We evaluated twenty renal transplant subjects at various stages of BKV nephritis (BKVN) for BKV-specific IgG and IgM antibodies using ELISA technique and BKV-DNA using PCR. They were divided as early onset (n = 7), stabilizing (n = 3), resolved (n = 8) and late onset (n = 2) BKVN. BKV-specific antibodies and BKV-DNA were simultaneously determined. The mean BKV-specific IgG level in early onset and stabilizing BKVN were 64 and 39 EIA units, and were significantly lower than 138 EIA units seen in resolved BKVN, P = 0.007, P = 0.008. The mean BKV-specific IgM levels in stabilizing BKVN was higher than resolved BKVN (130 vs 51 EIA units), P = 0.006. Mean plasma BKV loads for each group were 955,925, 5642 and 42 copies/mL of plasma, respectively. Prospective study in six BKVN cases revealed mean IgG, IgM levels and BKV-DNA at the time of diagnosis of BKVN as 39, 110 EIA units and 586,758 copies/mL of plasma, respectively. After a mean period of 5.2 months, IgG level increased to 120 EIA units (p = 0.0058) and had no detectable viral copies in circulation. Recovery from BKVN and elimination of BKV is associated with the development of BKV-specific IgG antibodies and this provides insight into the role of humoral immunity to BKV in the pathogenesis of BKVN.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1600-6135
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
5
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2719-24
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| pubmed:dateRevised |
2007-2-14
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| pubmed:meshHeading |
pubmed-meshheading:16212632-Adult,
pubmed-meshheading:16212632-Aged,
pubmed-meshheading:16212632-Antibodies, Viral,
pubmed-meshheading:16212632-BK Virus,
pubmed-meshheading:16212632-Creatinine,
pubmed-meshheading:16212632-Cross-Sectional Studies,
pubmed-meshheading:16212632-DNA, Viral,
pubmed-meshheading:16212632-Female,
pubmed-meshheading:16212632-Humans,
pubmed-meshheading:16212632-Immunoglobulin G,
pubmed-meshheading:16212632-Immunoglobulin M,
pubmed-meshheading:16212632-Kidney Transplantation,
pubmed-meshheading:16212632-Male,
pubmed-meshheading:16212632-Middle Aged,
pubmed-meshheading:16212632-Nephritis,
pubmed-meshheading:16212632-Pancreas Transplantation,
pubmed-meshheading:16212632-Polyomavirus Infections,
pubmed-meshheading:16212632-Time Factors,
pubmed-meshheading:16212632-Tumor Virus Infections,
pubmed-meshheading:16212632-Viremia
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| pubmed:year |
2005
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| pubmed:articleTitle |
BK virus-specific antibodies and BKV DNA in renal transplant recipients with BKV nephritis.
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| pubmed:affiliation |
The Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA. hari@mcw.edu
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| pubmed:publicationType |
Journal Article
|