|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2005-10-7
|
|
pubmed:abstractText |
Insulin-like growth factor binding protein-3 (IGFBP-3) is a mediator of growth suppression signals and a putative tumor suppressor gene. The growth suppression mechanisms of IGFBP-3 have not been well clarified. We examined the expression of IGFBP-3 transcripts in human hepatocellular carcinoma (HCC) and the relationship between IGFBP-3 expression and the transforming growth factor-beta (TGF-beta) and/or retinoblastoma (Rb) signaling pathways. In situ hybridization revealed IGFBP-3 transcripts in cancer cells in 6 of 57 (10%) HCCs, including moderately and poorly differentiated HCCs with intrahepatic metastasis. In contrast, all lung metastatic nodules of 4 HCCs showed IGFBP-3 transcripts in cancer cells. The cDNA microarray showed that genes for the TGF-beta pathway and Rb were up-regulated in IGFBP-3-expressing HCCs. In 6 HCCs presenting IGFBP-3, immunohistochemical analyses showed abnormalities in the TGF-beta and/or Rb pathways; the loss of phosphorylated-Smad2 was observed in 2, and overexpression of phosphorylated-Rb was observed in the remaining 4 HCCs. The present study suggests that IGFBP-3 mediates growth suppression signals via the TGF-beta and/or Rb pathways in HCC.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1019-6439
|
|
pubmed:author |
pubmed-author:FujikawaTatsuyaT,
pubmed-author:HanafusaTadashiT,
pubmed-author:MatsumotoEijiE,
pubmed-author:NakatsukasaHarushigeH,
pubmed-author:NousoKazuhiroK,
pubmed-author:OnishiToruT,
pubmed-author:ShiratoriYasushiY,
pubmed-author:SuzukiMayumiM,
pubmed-author:TakumaYoshitakaY,
pubmed-author:TanakaHironoriH,
pubmed-author:UemuraMasayukiM,
pubmed-author:YumotoEiichiroE,
pubmed-author:YumotoYasuhiroY
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1223-30
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16211216-Adult,
pubmed-meshheading:16211216-Aged,
pubmed-meshheading:16211216-Aged, 80 and over,
pubmed-meshheading:16211216-Carcinoma, Hepatocellular,
pubmed-meshheading:16211216-Case-Control Studies,
pubmed-meshheading:16211216-Cell Differentiation,
pubmed-meshheading:16211216-Female,
pubmed-meshheading:16211216-Gene Expression Profiling,
pubmed-meshheading:16211216-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16211216-Humans,
pubmed-meshheading:16211216-In Situ Hybridization,
pubmed-meshheading:16211216-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:16211216-Liver Neoplasms,
pubmed-meshheading:16211216-Lung Neoplasms,
pubmed-meshheading:16211216-Male,
pubmed-meshheading:16211216-Middle Aged,
pubmed-meshheading:16211216-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16211216-Retinoblastoma Protein,
pubmed-meshheading:16211216-Transforming Growth Factor beta,
pubmed-meshheading:16211216-Tumor Cells, Cultured,
pubmed-meshheading:16211216-Up-Regulation
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
IGFBP-3 expression in hepatocellular carcinoma involves abnormalities in TGF-beta and/or Rb signaling pathways.
|
|
pubmed:affiliation |
Department of Medicine, Okayama University Graduate School of Medicine and Dentistry, Japan. yumoto-gi@umin.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
