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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-10-7
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pubmed:abstractText |
The soluble decoy receptor 3 (DcR3) is a member of the TNFR superfamily. Because DcR3 is up-regulated in tumor tissues and is detectable in the sera of cancer patients, it is regarded as an immunosuppressor to down-regulate immune responses. To understand the function of DcR3 in vivo, we generated transgenic mice overexpressing DcR3 systemically. In comparison with HNT-TCR (HNT) transgenic mice, up-regulation of IL-4 and IL-10 and down-regulation of IFN-gamma, IL-12, and TNF-alpha were observed in the influenza hemagglutinin(126-138) peptide-stimulated splenocytes of HNT-DcR3 double-transgenic mice. When infected with Listeria monocytogenes, DcR3 transgenic mice show attenuated expression of IFN-gamma as well as increased susceptibility to infection. The Th2 cell-biased phenotype in DcR3 transgenic mice is attributed to decreased IL-2 secretion by T cells, resulting in the suppression of IL-2 dependent CD4(+) T cell proliferation. This suggests that DcR3 might help tumor growth by attenuating the Th1 response and suppressing cell-mediated immunity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/FASLG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fas Ligand Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Fasl protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF6B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF14 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF15 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf14 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor Ligand...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor Ligand...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5135-45
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16210617-Adjuvants, Immunologic,
pubmed-meshheading:16210617-Animals,
pubmed-meshheading:16210617-Apoptosis,
pubmed-meshheading:16210617-Cells, Cultured,
pubmed-meshheading:16210617-Cytokines,
pubmed-meshheading:16210617-Fas Ligand Protein,
pubmed-meshheading:16210617-Humans,
pubmed-meshheading:16210617-Immunity, Cellular,
pubmed-meshheading:16210617-Lymphocyte Activation,
pubmed-meshheading:16210617-Membrane Glycoproteins,
pubmed-meshheading:16210617-Membrane Proteins,
pubmed-meshheading:16210617-Mice,
pubmed-meshheading:16210617-Mice, Inbred BALB C,
pubmed-meshheading:16210617-Mice, Inbred MRL lpr,
pubmed-meshheading:16210617-Mice, Transgenic,
pubmed-meshheading:16210617-Receptors, Cell Surface,
pubmed-meshheading:16210617-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:16210617-Receptors, Tumor Necrosis Factor, Member 6b,
pubmed-meshheading:16210617-Th1 Cells,
pubmed-meshheading:16210617-Th2 Cells,
pubmed-meshheading:16210617-Tumor Necrosis Factor Ligand Superfamily Member 14,
pubmed-meshheading:16210617-Tumor Necrosis Factor Ligand Superfamily Member 15,
pubmed-meshheading:16210617-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16210617-Tumor Necrosis Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Attenuation of Th1 response in decoy receptor 3 transgenic mice.
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pubmed:affiliation |
Institute of Microbiology and Immunology, National Yang-Ming University, Shih-Pai, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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