Linked Life Data

1620738

Source:http://linkedlifedata.com/resource/pubmed/id/1620738

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-8-4
pubmed:abstractText
The crude extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br. has previously been shown to antagonize smooth muscle contractions induced by several agonists via a non-specific mechanism. Bioassay-guided fractionation of IPA resulted in isolation of the antispasmodically acting isoprenoids beta-damascenone and E-phytol. Their antispasmodic potencies were found to be in the same range as that of papaverine, a general spasmolytic agent. This effect was suggested to play a role in the previously observed anti-inflammatory activity of IPA by interfering with the contraction of endothelial cells. Severe vascular contraction has been shown to be involved in the dermatitis caused by toxic jellyfishes. It is possible that beta-damascenone and E-phytol, by interfering with the contraction of vascular smooth muscle cells, are partly responsible for the previously reported effectiveness of IPA in the treatment of such dermatitis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0032-0943
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Antispasmodic activity of beta-damascenone and E-phytol isolated from Ipomoea pes-caprae.
pubmed:affiliation
Department of Pharmacognosy, Uppsala University, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't