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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-8-14
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pubmed:abstractText |
Juvenile pilocytic astrocytomas (JPAs) are the most common central nervous system tumors in children. If completely resected, JPAs are associated with an excellent outcome. However, there is need for additional therapeutic approaches for those JPAs which are incompletely resected and fail subsequent standard chemotherapy/radiation. To explore the possibility for a novel therapeutic approach we measured the effect of the epidermal growth factor receptor (EGFR) small molecule tyrosine kinase inhibitor gefitinib on five JPA primary cell-cultures.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1545-5009
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
293-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16206208-Astrocytoma,
pubmed-meshheading:16206208-Cell Proliferation,
pubmed-meshheading:16206208-Central Nervous System Neoplasms,
pubmed-meshheading:16206208-Dose-Response Relationship, Drug,
pubmed-meshheading:16206208-Drug Screening Assays, Antitumor,
pubmed-meshheading:16206208-Flow Cytometry,
pubmed-meshheading:16206208-Gene Expression Profiling,
pubmed-meshheading:16206208-Humans,
pubmed-meshheading:16206208-Immunohistochemistry,
pubmed-meshheading:16206208-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16206208-Quinazolines,
pubmed-meshheading:16206208-RNA, Messenger,
pubmed-meshheading:16206208-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16206208-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16206208-Sensitivity and Specificity,
pubmed-meshheading:16206208-Thymidine,
pubmed-meshheading:16206208-Tumor Cells, Cultured
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pubmed:year |
2006
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pubmed:articleTitle |
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro.
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pubmed:affiliation |
University of Colorado at Denver and Health Sciences Center (UCDHSC) and The Children's Hospital, Denver, Colorado. foreman.nicholas@tchden.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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