Source:http://linkedlifedata.com/resource/pubmed/id/16206047
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2005-10-5
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pubmed:abstractText |
The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance by apoptosis of hepatic stellate cells (HSCs), which play a central role in liver fibrogenesis. In this study, the apoptotic effect of wogonin, oroxylin A, 2',5,6',7-tetrahydroxyflavone, skullcapflavone I, and baicalein, isolated from the dried root of Scutellaria baicalensis, was investigated in activated rat HSCs, T-HSC/Cl-6 cells transformed with the Simian virus 40. Among the isolated compounds, skullcapflavone I (20 microM for 24 h) significantly induced apoptosis in activated rat HSCs while there was no change in the cell viability of hepatocytes. Skullcapflavone I increased caspase-3 and -9 activities accompanied by the proteolytic cleavage of poly(ADP-ribose) polymerase. Specific inhibitors of caspase-3 and caspase-9 prevented the apoptotic process induced by skullcapflavone I. From these results, skullcapflavone I from S. baicalensis selectively induced apoptosis in T-HSC/Cl-6 cells via caspase-3 and caspase-9 activation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0032-0943
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
885-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16206047-Animals,
pubmed-meshheading:16206047-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:16206047-Apoptosis,
pubmed-meshheading:16206047-Caspases,
pubmed-meshheading:16206047-Cells, Cultured,
pubmed-meshheading:16206047-Flavones,
pubmed-meshheading:16206047-Flow Cytometry,
pubmed-meshheading:16206047-Liver,
pubmed-meshheading:16206047-Liver Cirrhosis,
pubmed-meshheading:16206047-Male,
pubmed-meshheading:16206047-Phytotherapy,
pubmed-meshheading:16206047-Plant Extracts,
pubmed-meshheading:16206047-Plant Roots,
pubmed-meshheading:16206047-Rats,
pubmed-meshheading:16206047-Rats, Sprague-Dawley,
pubmed-meshheading:16206047-Scutellaria baicalensis
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pubmed:year |
2005
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pubmed:articleTitle |
Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells.
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pubmed:affiliation |
Department of Pharmacy, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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