|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003865,
umls-concept:C0034693,
umls-concept:C0054433,
umls-concept:C0238790,
umls-concept:C0301625,
umls-concept:C0600686,
umls-concept:C0851285,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2006-2-10
|
|
pubmed:abstractText |
Simon extracts are vitamin K(1)-rich food materials extracted from the leaves of the Simon sweet potato. Although vitamin K is known to stimulate bone formation, we postulated that Simon extracts also contain unknown biological compounds having the ability to regulate bone resorption. Here we prepared the vitamin K-free fraction from the Simon extracts and investigated the ability of this fraction on the differentiation of osteoclasts. A remarkable inhibitory effect of osteoclastogenesis was observed when osteoclast precursors were treated with this fraction in rat bone marrow culture systems as well as in a pure differentiation system using murine osteoclast precursor cell line. The vitamin K-free Simon extracts markedly suppressed severe bone destruction mediated by abundant osteoclasts associated with adjuvant-induced arthritis in rats. High performance liquid chromatography (HPLC) analysis revealed that the vitamin K-free Simon extracts contained three types of low molecular weight inhibitors for osteoclastogenesis; caffeic acid, chlorogenic acids and isochlorogenic acids. Among these substances, caffeic acid showed the most powerful inhibitory effects on osteoclastogenesis. Caffeic acid significantly suppressed expression of NFATc1, a key transcription factor for the induction of osteoclastogenesis. Our current study enlightened a high utility of the Simon extracts and their chemical components as effective regulators for bone resorption accompanied with inflammation and metabolic bone diseases.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caffeic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin K,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsins,
http://linkedlifedata.com/resource/pubmed/chemical/Ctsk protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Glyceraldehyde-3-Phosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear...,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin K,
http://linkedlifedata.com/resource/pubmed/chemical/caffeic acid
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0948-6143
|
|
pubmed:author |
pubmed-author:IijimaTadahikoT,
pubmed-author:KawasakiSadamichiS,
pubmed-author:KukitaAkikoA,
pubmed-author:KukitaToshioT,
pubmed-author:KumagiMidoriM,
pubmed-author:MiyamotoIchikoI,
pubmed-author:NagataKengoK,
pubmed-author:OkumaYutakaY,
pubmed-author:RasubalaLindaL,
pubmed-author:SandraFerryF,
pubmed-author:TangQuan YongQY,
pubmed-author:TeramachiJunpeiJ,
pubmed-author:TohKazukoK,
pubmed-author:UshijimaYukiY,
pubmed-author:ZhouWuW
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
125
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
215-25
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16205940-Animals,
pubmed-meshheading:16205940-Arthritis, Experimental,
pubmed-meshheading:16205940-Base Sequence,
pubmed-meshheading:16205940-Bone Resorption,
pubmed-meshheading:16205940-Caffeic Acids,
pubmed-meshheading:16205940-Cathepsin K,
pubmed-meshheading:16205940-Cathepsins,
pubmed-meshheading:16205940-Cells, Cultured,
pubmed-meshheading:16205940-DNA Primers,
pubmed-meshheading:16205940-Glyceraldehyde-3-Phosphate Dehydrogenases,
pubmed-meshheading:16205940-Ipomoea batatas,
pubmed-meshheading:16205940-Male,
pubmed-meshheading:16205940-Osteoclasts,
pubmed-meshheading:16205940-Phytotherapy,
pubmed-meshheading:16205940-Plant Extracts,
pubmed-meshheading:16205940-Rats,
pubmed-meshheading:16205940-Rats, Inbred Lew,
pubmed-meshheading:16205940-Rats, Sprague-Dawley,
pubmed-meshheading:16205940-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:16205940-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16205940-Vitamin K
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats.
|
|
pubmed:affiliation |
Oral Cellular and Molecular Biology, Kyushu University, Maidashi 3-1-1, Fukuoka, 812-8582, Japan.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
