Linked Life Data

16205775

Source:http://linkedlifedata.com/resource/pubmed/id/16205775

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-6-16
pubmed:abstractText
Enhanced dopamine transmission in the nucleus accumbens plays an important role in cocaine priming-induced reinstatement of drug-seeking behavior. However, the contribution of each dopamine receptor subtype to this behavior remains unclear. The present experiments were designed to assess the role of D2-like dopamine receptors in the nucleus accumbens core and shell subregions in cocaine priming-induced reinstatement of drug seeking. Rats were trained to lever press for cocaine using a fixed ratio (FR) 5 schedule of reinforcement. After approximately 18 days of cocaine self-administration, the animals underwent an extinction phase during which cocaine was replaced with saline. Daily extinction sessions were conducted until responding was less than 10% of the response rate maintained by cocaine self-administration. Following the extinction phase, priming-induced reinstatement of cocaine-seeking behavior was assessed. A range of doses of antagonists selective for D2- (sulpiride, 0.2 or 2.0 microg), D3- (U99194A, 3.9 or 7.8 microg), or D4- (L-750,667, 5.5 or 11 microg) dopamine receptors were microinjected into either the nucleus accumbens core, shell or lateral septum prior to a priming injection of cocaine (10 mg/kg, i.p.). Following administration into the shell, but not core or lateral septum, sulpiride dose-dependently attenuated reinstatement induced by a cocaine priming injection. In contrast, U99194A and L-750,667 failed to influence cocaine seeking at any of the doses tested in either accumbal subregion. Collectively, these findings indicate that activation of D2 dopamine receptors mediates cocaine priming-induced reinstatement of cocaine seeking in a region-specific manner within the nucleus accumbens.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1452-61
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed-meshheading:16205775-Analysis of Variance, pubmed-meshheading:16205775-Animals, pubmed-meshheading:16205775-Behavior, Addictive, pubmed-meshheading:16205775-Behavior, Animal, pubmed-meshheading:16205775-Cocaine, pubmed-meshheading:16205775-Conditioning, Operant, pubmed-meshheading:16205775-Dopamine Antagonists, pubmed-meshheading:16205775-Dopamine Uptake Inhibitors, pubmed-meshheading:16205775-Dose-Response Relationship, Drug, pubmed-meshheading:16205775-Drug Interactions, pubmed-meshheading:16205775-Extinction, Psychological, pubmed-meshheading:16205775-Indans, pubmed-meshheading:16205775-Male, pubmed-meshheading:16205775-Microinjections, pubmed-meshheading:16205775-Nucleus Accumbens, pubmed-meshheading:16205775-Pyridines, pubmed-meshheading:16205775-Pyrroles, pubmed-meshheading:16205775-Rats, pubmed-meshheading:16205775-Rats, Sprague-Dawley, pubmed-meshheading:16205775-Reinforcement Schedule, pubmed-meshheading:16205775-Self Administration, pubmed-meshheading:16205775-Sulpiride
pubmed:year
2006
pubmed:articleTitle
Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking.
pubmed:affiliation
Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural