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16203140
Source:
http://linkedlifedata.com/resource/pubmed/id/16203140
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Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0064239
,
umls-concept:C0205250
,
umls-concept:C0443288
,
umls-concept:C1883695
pubmed:issue
23
pubmed:dateCreated
2005-10-19
pubmed:abstractText
Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid
,
http://linkedlifedata.com/resource/pubmed/chemical/Benzofurans
,
http://linkedlifedata.com/resource/pubmed/chemical/Chromans
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa
,
http://linkedlifedata.com/resource/pubmed/chemical/coumaran
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0960-894X
pubmed:author
pubmed-author:BelangerSergeS
,
pubmed-author:CasselJoel AJA
,
pubmed-author:ChuGuo-HuaGH
,
pubmed-author:Conway-JamesNathalieN
,
pubmed-author:DeHaven-HudkinsDiane LDL
,
pubmed-author:DeHavenRobert NRN
,
pubmed-author:DolleRoland ERE
,
pubmed-author:GraczykThomas MTM
,
pubmed-author:GuMinghuaM
,
pubmed-author:KoblishMikeM
,
pubmed-author:LittlePatrick JPJ
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5114-9
pubmed:meshHeading
pubmed-meshheading:16203140-Amides
,
pubmed-meshheading:16203140-Analgesics, Opioid
,
pubmed-meshheading:16203140-Animals
,
pubmed-meshheading:16203140-Benzofurans
,
pubmed-meshheading:16203140-Chromans
,
pubmed-meshheading:16203140-Humans
,
pubmed-meshheading:16203140-Receptors, Opioid, kappa
pubmed:year
2005
pubmed:articleTitle
Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints.
pubmed:affiliation
Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA. ghchu@adolor.com
pubmed:publicationType
Journal Article