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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-10-5
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pubmed:abstractText |
The purpose of this study was to test the hypothesis that after thoracic surgery, the supplementation of a low-dose thoracic epidural (ED) bupivacaine (0.125%) infusion by intravenous (IV) dexmedetomidine decreases analgesic requirement without causing respiratory depression. The primary endpoint was the need for additional ED bupivacaine administered through patient-controlled epidural analgesia (PCEA). Secondary endpoints included the requirement for supplemental opioids and the impact of dexmedetomidine on CO2 retention.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1053-0770
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
630-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16202898-Adult,
pubmed-meshheading:16202898-Aged,
pubmed-meshheading:16202898-Analgesia, Epidural,
pubmed-meshheading:16202898-Analgesia, Patient-Controlled,
pubmed-meshheading:16202898-Analgesics, Non-Narcotic,
pubmed-meshheading:16202898-Anesthetics, Local,
pubmed-meshheading:16202898-Blood Gas Analysis,
pubmed-meshheading:16202898-Blood Pressure,
pubmed-meshheading:16202898-Bupivacaine,
pubmed-meshheading:16202898-Dexmedetomidine,
pubmed-meshheading:16202898-Dose-Response Relationship, Drug,
pubmed-meshheading:16202898-Double-Blind Method,
pubmed-meshheading:16202898-Female,
pubmed-meshheading:16202898-Heart Rate,
pubmed-meshheading:16202898-Humans,
pubmed-meshheading:16202898-Infusions, Intravenous,
pubmed-meshheading:16202898-Male,
pubmed-meshheading:16202898-Middle Aged,
pubmed-meshheading:16202898-Pain, Postoperative,
pubmed-meshheading:16202898-Pain Measurement,
pubmed-meshheading:16202898-Postoperative Care,
pubmed-meshheading:16202898-Prospective Studies,
pubmed-meshheading:16202898-Thoracic Surgical Procedures,
pubmed-meshheading:16202898-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
A prospective, double-blind, randomized, placebo-controlled study of dexmedetomidine as an adjunct to epidural analgesia after thoracic surgery.
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pubmed:affiliation |
Department of Anesthesiology, Division of Critical Care Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032-3784, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial
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