Linked Life Data

16202711

Source:http://linkedlifedata.com/resource/pubmed/id/16202711

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16202711rdf:typepubmed:Citationlld:pubmed
pubmed-article:16202711lifeskim:mentionsumls-concept:C0027763lld:lifeskim
pubmed-article:16202711lifeskim:mentionsumls-concept:C0332281lld:lifeskim
pubmed-article:16202711lifeskim:mentionsumls-concept:C0040649lld:lifeskim
pubmed-article:16202711lifeskim:mentionsumls-concept:C0013138lld:lifeskim
pubmed-article:16202711lifeskim:mentionsumls-concept:C1707919lld:lifeskim
pubmed-article:16202711lifeskim:mentionsumls-concept:C0392747lld:lifeskim
pubmed-article:16202711pubmed:issue1lld:pubmed
pubmed-article:16202711pubmed:dateCreated2005-10-5lld:pubmed
pubmed-article:16202711pubmed:abstractTextNeuronal plasticity is an important feature of the developing brain and requires neuronal circuits to reconfigure their functional connectivity depending upon activity patterns. To explore changes in neuronal function that occur downstream of altered activity, we performed an expression analysis in Drosophila mutants with acute or chronic alterations in neuronal activity. We find that seizure induction leads to an overproliferation of synaptic connections, indicating that activity-dependent neuronal rewiring occurs in Drosophila. To analyze transcriptional recoding during altered neuronal activity, we performed genome-wide DNA microarray analysis following multiple seizure induction and recovery paradigms. Approximately 250 genes implicated in cell adhesion, membrane excitability, and cellular signaling are differentially regulated, including the Kek 2 neuronal cell adhesion protein, which, as we demonstrate, functions as a regulator of synaptic growth. These data identify a collection of activity-regulated transcripts that may link changes in neuronal firing patterns to transcription-dependent modulation of brain function, including activity-dependent synaptic rewiring.lld:pubmed
pubmed-article:16202711pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:languageenglld:pubmed
pubmed-article:16202711pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:citationSubsetIMlld:pubmed
pubmed-article:16202711pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16202711pubmed:statusMEDLINElld:pubmed
pubmed-article:16202711pubmed:monthOctlld:pubmed
pubmed-article:16202711pubmed:issn0896-6273lld:pubmed
pubmed-article:16202711pubmed:authorpubmed-author:GuanZhuoZlld:pubmed
pubmed-article:16202711pubmed:authorpubmed-author:LittletonJ...lld:pubmed
pubmed-article:16202711pubmed:authorpubmed-author:AdolfsenBillBlld:pubmed
pubmed-article:16202711pubmed:authorpubmed-author:SaraswatiSudi...lld:pubmed
pubmed-article:16202711pubmed:issnTypePrintlld:pubmed
pubmed-article:16202711pubmed:day6lld:pubmed
pubmed-article:16202711pubmed:volume48lld:pubmed
pubmed-article:16202711pubmed:ownerNLMlld:pubmed
pubmed-article:16202711pubmed:authorsCompleteYlld:pubmed
pubmed-article:16202711pubmed:pagination91-107lld:pubmed
pubmed-article:16202711pubmed:dateRevised2011-3-2lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:meshHeadingpubmed-meshheading:16202711...lld:pubmed
pubmed-article:16202711pubmed:year2005lld:pubmed
pubmed-article:16202711pubmed:articleTitleGenome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system.lld:pubmed
pubmed-article:16202711pubmed:affiliationThe Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.lld:pubmed
pubmed-article:16202711pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16202711pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:16202711pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:16202711pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16202711pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
entrez-gene:32007entrezgene:pubmedpubmed-article:16202711lld:entrezgene
entrez-gene:42940entrezgene:pubmedpubmed-article:16202711lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16202711lld:pubmed