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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-11-25
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pubmed:abstractText |
Thiopurines are used in the treatment of inflammatory bowel disease. They are metabolised via methylation by thiopurine-S-methyltransferase (TPMT), which displays a genetically determined polymorphic activity. Subjects with reduced TPMT activity have a higher concentration of active thiopurine metabolites and may be at increased risk of bone-marrow suppression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1590-8658
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pubmed:author |
pubmed-author:BarabinoAA,
pubmed-author:BartoliFF,
pubmed-author:DecortiGG,
pubmed-author:FezziMM,
pubmed-author:FontanaMM,
pubmed-author:GiraldiTT,
pubmed-author:LionettiPP,
pubmed-author:MalusàNN,
pubmed-author:MartelossiSS,
pubmed-author:StoccoGG,
pubmed-author:VenturaAA
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
940-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16202677-6-Mercaptopurine,
pubmed-meshheading:16202677-Adolescent,
pubmed-meshheading:16202677-Adult,
pubmed-meshheading:16202677-Azathioprine,
pubmed-meshheading:16202677-Bone Marrow Diseases,
pubmed-meshheading:16202677-Child,
pubmed-meshheading:16202677-Child, Preschool,
pubmed-meshheading:16202677-Dose-Response Relationship, Drug,
pubmed-meshheading:16202677-Drug-Induced Liver Injury,
pubmed-meshheading:16202677-Female,
pubmed-meshheading:16202677-Genotype,
pubmed-meshheading:16202677-Humans,
pubmed-meshheading:16202677-Immunosuppressive Agents,
pubmed-meshheading:16202677-Infant,
pubmed-meshheading:16202677-Inflammatory Bowel Diseases,
pubmed-meshheading:16202677-Male,
pubmed-meshheading:16202677-Methyltransferases,
pubmed-meshheading:16202677-Pancreatitis,
pubmed-meshheading:16202677-Polymorphism, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease.
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pubmed:affiliation |
Department of Biomedical Sciences, University of Trieste, Via L.Giorgieri 7,9, Italy. stoccog@units.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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