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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-10-19
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pubmed:abstractText |
A C1173T polymorphism in intron 1 of the VKORC1 gene has been claimed to determine the interindividual variability in the response to vitamin K antagonist therapy (VKA), but it is unknown whether it also influences bleeding risk. We aimed to confirm the relationship between C1173T status and phenprocoumon or acenocoumarol use, and to examine the risk of severe bleeding for the various genotypes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-12060134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-14388528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-14765194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-14765195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-15213846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-15219193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-15358623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-15790782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-15930419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-16231978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16201835-16626259
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1549-1676
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e312
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16201835-Acenocoumarol,
pubmed-meshheading:16201835-Anticoagulants,
pubmed-meshheading:16201835-Case-Control Studies,
pubmed-meshheading:16201835-Genetic Predisposition to Disease,
pubmed-meshheading:16201835-Genotype,
pubmed-meshheading:16201835-Hemorrhage,
pubmed-meshheading:16201835-Humans,
pubmed-meshheading:16201835-Mixed Function Oxygenases,
pubmed-meshheading:16201835-Phenprocoumon,
pubmed-meshheading:16201835-Polymorphism, Genetic,
pubmed-meshheading:16201835-Risk Factors,
pubmed-meshheading:16201835-Vitamin K
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pubmed:year |
2005
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pubmed:articleTitle |
A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk.
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pubmed:affiliation |
Laboratory for Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. p.h.reitsma@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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