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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-10-5
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pubmed:abstractText |
Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ----> [corrected] Gln, Arg 3500 ----> [corrected] Trp and Arg 3531 ----> [corrected] Cys). We estimated the frequency of Apo B point mutations (codon 3500) C9774T (Arg 3500 ----> [corrected] Trp) and G9775A (Arg 3500 ----> [corrected] Gln) in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1020-3397
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-30
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16201717-Adult,
pubmed-meshheading:16201717-Apolipoprotein B-100,
pubmed-meshheading:16201717-Apolipoproteins A,
pubmed-meshheading:16201717-Apolipoproteins B,
pubmed-meshheading:16201717-Arteriosclerosis,
pubmed-meshheading:16201717-Case-Control Studies,
pubmed-meshheading:16201717-Causality,
pubmed-meshheading:16201717-Cholesterol, HDL,
pubmed-meshheading:16201717-Cholesterol, LDL,
pubmed-meshheading:16201717-Cholesterol, VLDL,
pubmed-meshheading:16201717-Female,
pubmed-meshheading:16201717-Gene Frequency,
pubmed-meshheading:16201717-Humans,
pubmed-meshheading:16201717-Hypercholesterolemia,
pubmed-meshheading:16201717-Male,
pubmed-meshheading:16201717-Mediterranean Region,
pubmed-meshheading:16201717-Middle Aged,
pubmed-meshheading:16201717-Molecular Epidemiology,
pubmed-meshheading:16201717-Point Mutation,
pubmed-meshheading:16201717-Polymerase Chain Reaction,
pubmed-meshheading:16201717-Polymorphism, Genetic,
pubmed-meshheading:16201717-Population Surveillance,
pubmed-meshheading:16201717-Rare Diseases,
pubmed-meshheading:16201717-Triglycerides,
pubmed-meshheading:16201717-Turkey
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pubmed:articleTitle |
Apolipoprotein B gene polymorphisms in people in the east Mediterranean area of Turkey.
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pubmed:affiliation |
Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey.
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pubmed:publicationType |
Journal Article
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