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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1992-8-6
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pubmed:abstractText |
Oct-2 is a transcription factor that binds specifically to octamer DNA motifs in the promoters of immunoglobulin and interleukin-2 genes. All tumor cell lines from the B-cell lineage and a few from the T-cell lineage express Oct-2. To address the role of Oct-2 in the T-cell lineage, we studied the expression of Oct-2 mRNA and protein in nontransformed human and mouse T cells. Oct-2 was found in CD4+ and CD8+ T cells prepared from human peripheral blood and in mouse lymph node T cells. In a T-cell clone specific for pigeon cytochrome c in the context of I-Ek, Oct-2 was induced by antigen stimulation, with the increase in Oct-2 protein seen first at 3 h after activation and continuing for at least 24 h. Oct-2 mRNA induction during antigen-driven T-cell activation was blocked by cyclosporin A, as well as by protein synthesis inhibitors. These results suggest that Oct-2 participates in transcriptional regulation during T-cell activation. The relatively delayed kinetics of Oct-2 induction suggests that Oct-2 mediates the changes in gene expression which occur many hours or days following antigen stimulation of T lymphocytes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1683003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1702384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1757474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1827817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1900081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1910683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1972777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-1976089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2106071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2110381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2123468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2188669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2204815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2369902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2407588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-2555786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3006925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3012540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3015413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3072196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3095662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3215510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3260003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3399892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-3491296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1620122-6193170
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-2,
http://linkedlifedata.com/resource/pubmed/chemical/POU2F2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3149-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1620122-Animals,
pubmed-meshheading:1620122-Antigens, CD4,
pubmed-meshheading:1620122-Antigens, CD8,
pubmed-meshheading:1620122-Base Sequence,
pubmed-meshheading:1620122-Clone Cells,
pubmed-meshheading:1620122-Cyclosporine,
pubmed-meshheading:1620122-DNA-Binding Proteins,
pubmed-meshheading:1620122-Gene Expression Regulation,
pubmed-meshheading:1620122-Humans,
pubmed-meshheading:1620122-Lymph Nodes,
pubmed-meshheading:1620122-Lymphocyte Activation,
pubmed-meshheading:1620122-Mice,
pubmed-meshheading:1620122-Molecular Sequence Data,
pubmed-meshheading:1620122-Octamer Transcription Factor-2,
pubmed-meshheading:1620122-RNA, Messenger,
pubmed-meshheading:1620122-T-Lymphocytes,
pubmed-meshheading:1620122-Transcription Factors
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pubmed:year |
1992
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pubmed:articleTitle |
Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Comparative Study
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