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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-10-11
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pubmed:abstractText |
Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with massive T cell infiltration into the synovium. The accumulated T cells express type 1 cytokines, such as interferon-gamma (IFNgamma) and tumor necrosis factor alpha, and activated markers of inflammation, such as CD154 and inducible costimulator (ICOS). It is thought that chemokines contribute to T cell accumulation in the synovium. In this study, we examined the role of CXCL16 and CXCR6 in T cell migration and stimulation in RA synovium.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/CXCL16 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL6,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl16 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3004-14
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16200580-Aged,
pubmed-meshheading:16200580-Animals,
pubmed-meshheading:16200580-Antibodies, Monoclonal,
pubmed-meshheading:16200580-Arthritis, Rheumatoid,
pubmed-meshheading:16200580-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16200580-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16200580-Chemokine CXCL6,
pubmed-meshheading:16200580-Chemokines, CXC,
pubmed-meshheading:16200580-Female,
pubmed-meshheading:16200580-Humans,
pubmed-meshheading:16200580-Male,
pubmed-meshheading:16200580-Membrane Proteins,
pubmed-meshheading:16200580-Mice,
pubmed-meshheading:16200580-Mice, Inbred DBA,
pubmed-meshheading:16200580-Middle Aged,
pubmed-meshheading:16200580-Receptors, Chemokine,
pubmed-meshheading:16200580-Receptors, Cytokine,
pubmed-meshheading:16200580-Receptors, G-Protein-Coupled,
pubmed-meshheading:16200580-Receptors, Immunologic,
pubmed-meshheading:16200580-Receptors, Scavenger,
pubmed-meshheading:16200580-Receptors, Virus,
pubmed-meshheading:16200580-Synovial Membrane
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pubmed:year |
2005
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pubmed:articleTitle |
Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis.
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pubmed:affiliation |
Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan. nanki.rheu@tmd.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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