| pubmed-article:16200067 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16200067 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16200067 | lifeskim:mentions | umls-concept:C0034789 | lld:lifeskim |
| pubmed-article:16200067 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:16200067 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:16200067 | lifeskim:mentions | umls-concept:C0597717 | lld:lifeskim |
| pubmed-article:16200067 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16200067 | pubmed:dateCreated | 2005-10-21 | lld:pubmed |
| pubmed-article:16200067 | pubmed:abstractText | Binding of antigen to the B cell antigen receptor (BCR) triggers signaling that ultimately leads to B cell activation. Using quantitative fluorescence resonance energy transfer imaging, we provide evidence here that the BCR is a monomer on the surface of resting cells. Binding of multivalent antigen clustered the BCR, resulting in the simultaneous phosphorylation of and a conformational change in the BCR cytoplasmic domains from a closed to an open form. Notably, the open conformation required immunoreceptor tyrosine-activation motif and continuous Src family kinase activity but not binding of the kinase Syk. Thus, the initiation of BCR signaling is a very dynamic process accompanied by reversible conformational changes induced by Src family kinase activity. | lld:pubmed |
| pubmed-article:16200067 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16200067 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16200067 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16200067 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16200067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16200067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16200067 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16200067 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16200067 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:16200067 | pubmed:author | pubmed-author:PierceSusan... | lld:pubmed |
| pubmed-article:16200067 | pubmed:author | pubmed-author:SohnHae WonHW | lld:pubmed |
| pubmed-article:16200067 | pubmed:author | pubmed-author:TolarPavelP | lld:pubmed |
| pubmed-article:16200067 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16200067 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:16200067 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16200067 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16200067 | pubmed:pagination | 1168-76 | lld:pubmed |
| pubmed-article:16200067 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:16200067 | pubmed:meshHeading | pubmed-meshheading:16200067... | lld:pubmed |
| pubmed-article:16200067 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16200067 | pubmed:articleTitle | The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer. | lld:pubmed |
| pubmed-article:16200067 | pubmed:affiliation | Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA. | lld:pubmed |
| pubmed-article:16200067 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16200067 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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