Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-2-6
pubmed:abstractText
To eliminate user interaction in longitudinal quantitative computed tomography (QCT) measurements of bone mineral density (BMD) and geometry, we have developed and optimized an automated registration algorithm for QCT images of the hip and spine and integrated it with a previously developed 3D densitometric and structural analysis program. With registration, the follow-up images are automatically aligned with respect to the baseline scans, and the bone quantification of the aligned follow-up scan is initiated based on the bone morphometric features defined on the baseline scan. To validate the algorithm, we analyzed 20 pairs of repeat QCT images (10 hip pairs and 10 spine pairs) acquired on a modern multi-slice CT scanner, with repositioning between each scan pair to simulate repeat visits. Bone measurements obtained with automatic registration achieved comparable or improved precision errors compared to those obtained by careful manual analysis of the follow-up scans. The algorithm we have developed was based on the mutual information approach, with simplex optimization under a multi-resolution scheme. The average registration time was 2.3 min for a hip pair and 1.1 min for a vertebra pair using a standard desktop computer. Based on the reduced user interaction, high degree of precision, and short execution time, this is a promising technique for monitoring therapy in patients and clinical trials.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-10050823, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-10476839, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-11277237, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-11346808, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-11410381, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-11477303, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-11850479, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-11893367, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-12557971, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-12643549, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-12931320, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-14500804, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-14596313, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-14602862, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-14710506, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-15125798, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-2493329, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-3310091, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-7917575, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-8293353, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-9029539, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-9213015, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-9443925, http://linkedlifedata.com/resource/pubmed/commentcorrection/16199215-9873927
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
8756-3282
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-9
pubmed:dateRevised
2011-3-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Automated registration of hip and spine for longitudinal QCT studies: integration with 3D densitometric and structural analysis.
pubmed:affiliation
Department of Radiology, University of California at San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94143-0946, USA. Wenjun.Li@radiology.ucsf.edu
pubmed:publicationType
Journal Article, Comparative Study, Evaluation Studies, Research Support, N.I.H., Extramural