Linked Life Data

16197255

Source:http://linkedlifedata.com/resource/pubmed/id/16197255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2005-10-3
pubmed:abstractText
Patterns and forms adopted by nature are often the results of simple dynamical paradigms. Here we show that a growing self-interacting string attached to a tracking origin, modeled to resemble nascent polypeptides in vivo, develops helical structures which are more pronounced at the growing end. We also show that the dynamic growth ensemble shares several features of an equilibrium ensemble in which the growing end of the polymer is under an effective stretching force. A statistical analysis of native states of proteins shows that the signature of this nonequilibrium phenomenon has been fixed by evolution at the C terminus, the growing end of a nascent protein. These findings suggest how evolution may have built on the properties of a generic nonequilibrium growth process in favoring helical structures in nascent chains.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-9007
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
098103
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Form of growing strings.
pubmed:affiliation
Mathematics Institute, University of Warwick, Coventry CV4 7AL, England, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't