Source:http://linkedlifedata.com/resource/pubmed/id/16193975
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2005-9-30
|
| pubmed:abstractText |
The therapeutic effect of Fe2O3 nanoparticles combined with magnetic fluid hyperthermia (MFH) on human hepatocarcinoma SMMC-7721 cells in vitro and xenograft liver cancer in nude mice is studied. We examined growth and apoptosis of SMMC-7721 cells treated with MFH containing Fe2O3 nanoparticles at various concentrations (2, 4, 6, and 8 g/liter) for 30-60 min by using MTT, flow cytometry (FCM), and transmission electron microscopy (TEM). We also observed weight and volume inhibitory rates of the tumors of SMMC-7721-bearing nude mice by using animal experiments. The results showed that Fe2O3 nanoparticles combined with MFH could significantly inhibit the proliferation and increase the ratio of apoptosis of SMMC-7721 cells, and the effect was dose-dependent. The inhibitory rate was 26.5%, 33.53%, 54.4%, and 81.2%, respectively, and the apoptosis rate was 30.26%, 38.65%, 50.28%, and 69.33%, respectively. Animal experiments showed that tumors became small. The weight inhibitory ratio was 42.10%, 66.34%, 78.5%, and 91.46%, and the volume inhibitory ratio was 58.77%, 80.44%, 93.40%, and 98.30%, respectively. Compared with the control and experimental groups, each group had statistically significant difference (p < 0.05). So, Fe2O3 nanoparticles combined with MFH could inhibit the proliferation and induce apoptosis of SMMC-7721 cells and also has a significant inhibitory effect on the weight and volume of xenograft liver cancer. However, the mechanism remains to be further investigated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1533-4880
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1185-92
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16193975-Animals,
pubmed-meshheading:16193975-Apoptosis,
pubmed-meshheading:16193975-Carcinoma, Hepatocellular,
pubmed-meshheading:16193975-Cell Line, Tumor,
pubmed-meshheading:16193975-Cell Proliferation,
pubmed-meshheading:16193975-Combined Modality Therapy,
pubmed-meshheading:16193975-Ferric Compounds,
pubmed-meshheading:16193975-Humans,
pubmed-meshheading:16193975-Hyperthermia, Induced,
pubmed-meshheading:16193975-Liver Neoplasms,
pubmed-meshheading:16193975-Magnetics,
pubmed-meshheading:16193975-Male,
pubmed-meshheading:16193975-Mice,
pubmed-meshheading:16193975-Mice, Inbred BALB C,
pubmed-meshheading:16193975-Mice, Nude,
pubmed-meshheading:16193975-Microscopy, Electron,
pubmed-meshheading:16193975-Nanostructures,
pubmed-meshheading:16193975-Transplantation, Heterologous
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Therapeutic effect of Fe2O3 nanoparticles combined with magnetic fluid hyperthermia on cultured liver cancer cells and xenograft liver cancers.
|
| pubmed:affiliation |
Department of Pathology and Pathophysiology, Institute of Molecular Pathology, School of Basic Medical Sciences, Southeast University, Nanjing 210096, Jiangsu, P R. China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|