Linked Life Data

16193861

Source:http://linkedlifedata.com/resource/pubmed/id/16193861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2005-9-30
pubmed:abstractText
This review seeks to bring novel findings of genetic basis of melanoma. CDKN2A and CDK4 genes residing on chromosomes 9p21 and 12q14, as well as MC1R gene located at 16q24 are main candidates responsible for melanoma development and progression. These genes together with signal transduction pathways in which they are implied are primarily changed in hereditary melanoma. Moreover, changes of genes: BRAF, RAS, c-MET and PTEN characterize sporadic forms of melanoma. Today's knowledge on melanoma genetics is rather inconsistent and involves different genes and signalling pathways. Series of consecutive genetic events that lead to melanoma progression is a very dinamic scientific field in medicine.
pubmed:language
hrv
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0024-3477
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-93
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:articleTitle
[New insights on genetics of malignant melanoma].
pubmed:affiliation
Klinika za ginekologiju i porodiljstvo, KB Merkur, Zagreb.
pubmed:publicationType
Journal Article, English Abstract, Review, Research Support, Non-U.S. Gov't