Linked Life Data

1619187

Source:http://linkedlifedata.com/resource/pubmed/id/1619187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-8-3
pubmed:abstractText
Initially characterized in uremic patients undergoing hemodialysis, toxic effects due to high aluminum (Al) body loads were subsequently observed in a number of conditions, in particular following ingestion of Al-containing antacids. Among compounds of this class, aluminum phosphate (AlPO4) was recognized as safer than aluminum hydroxide (Al(OH)3), which was thought to result from its lower solubility and thus absorption in the gastrointestinal (gi) tract. However, while virtually insoluble at acid pH, AlPO4 is more soluble than Al(OH)3 under alkaline conditions, leading to the hypothesis that Al is predominantly absorbed in the acidic region of the gi tract. Our present results suggest otherwise. Al bioavailability depends on the solubility of the salt ingested as well as on the physicochemical properties of the Al soluble complexes formed in the gi fluid. Anions of dietary acids may indeed dissolve significant fractions of Al salts and form absorbable Al complexes. It is in these terms that the well documented increase of Al gi absorption by citrate has been interpreted from computer-based speciation studies. Using similar calculations, we now demonstrate that a series of dietary acids (namely malic, oxalic, tartaric, succinic, aspartic and glutamic acids) can also dissolve significant amounts of Al(OH)3 and form Al neutral complexes available to the gi membrane. In contrast, both effects are far less apparent when Al is administered as AlPO4. We conclude from this observation that the lower toxicity of AlPO4 vs Al(OH)3 stems from its better capacity to resist dissolution and neutral complex formation in the presence of acids commonly present in food.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0731-5724
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
340-8
pubmed:dateRevised
2008-6-23
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Why aluminum phosphate is less toxic than aluminum hydroxide.
pubmed:affiliation
Inserm U305, Equipe Bioréactifs: Spéciation et Biodisponibilité, Université Paul Sabatier, Toulouse, France.
pubmed:publicationType
Journal Article, Comparative Study, Review, Research Support, Non-U.S. Gov't