Source:http://linkedlifedata.com/resource/pubmed/id/16189667
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2005-10-18
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pubmed:abstractText |
Interleukin (IL) 4 is a key T helper-2 cytokine that downregulates and upregulates CCR5 and CXCR4, respectively, the main coreceptors for HIV. Our objective is to investigate whether single-nucleotide polymorphisms (SNPs) in the IL-4 receptor alpha chain gene (IL4RA) affect HIV infection and its progression to AIDS. The I50V SNP in exon 5 and the haplotypes of six SNPs in exon 12 (E375A, C406R, S411L, S478P, Q551R, and V554I) were studied by polymerase chain reaction and sequencing in 30 HIV+ long-term nonprogressors (LTNP), 36 HIV+ typical progressors (TP), 55 highly exposed but uninfected individuals (EU), 25 EU-sexuals (EU-Sex; mostly women) and 30 EU-hemophiliacs (EU-Hem; hepatitis C virus+), and 97 healthy controls (HC), all Caucasians and lacking CCR5Delta32 homozygosity. V50 homozygosity was increased in LTNP (44%) compared with the other groups [p = 0.005; relative risk ratio = 3.4, 95% confidence interval (CI) = 1.12-10.6, p = 0.03]. The most common (C) exon 12 haplotype, ECSSQV, predominated in all groups, but uncommon (U) haplotypes were increased in HIV+ individuals (n = 64), especially in those (51 of 64) infected via parenteral exposure (35.3%) compared with HC (20.4%) and EU-Hem (18.4%) [p = 0.01; odds ratio (OR) = 2.14, 95% CI = 1.25-3.67, p = 0.01]. EU-Sex also had an increased frequency of U-haplotypes (34.8%) (OR = 2.10, 95% CI = 1.03-4.21, p = 0.01) as well as an increased frequency of CU + UU genotypes (60.9%) compared with HC (38.2%) and EU-Hem (26.6%) (p = 0.043). Distributions of genotypes fitted Hardy-Weinberg equilibrium. Data suggest that V50 homozygosity associates with slow progression and that exon 12 U-haplotypes might be associated with both susceptibility to infection via parenteral route and resistance to infection via sexual exposure. Further studies are required to confirm these findings.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/IL4R protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4 Receptor alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0093-7711
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pubmed:author |
pubmed-author:BarrasaAliciaA,
pubmed-author:De LazzariElisaE,
pubmed-author:Del RomeroJorgeJ,
pubmed-author:GallartTeresaT,
pubmed-author:GarcíaFelipeF,
pubmed-author:GatellJosé MJM,
pubmed-author:LorenzoJosé IJI,
pubmed-author:LozanoFranciscoF,
pubmed-author:MiróJosé MJM,
pubmed-author:NomdedéuMeritxellM,
pubmed-author:OlivaHaroldH,
pubmed-author:PlanaMontserratM,
pubmed-author:RodríguezCarmenC,
pubmed-author:SorianoAlexA,
pubmed-author:VivesJordiJ
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
644-54
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16189667-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:16189667-Exons,
pubmed-meshheading:16189667-Female,
pubmed-meshheading:16189667-Gene Frequency,
pubmed-meshheading:16189667-Genetic Predisposition to Disease,
pubmed-meshheading:16189667-Genotype,
pubmed-meshheading:16189667-HIV Infections,
pubmed-meshheading:16189667-Haplotypes,
pubmed-meshheading:16189667-Homozygote,
pubmed-meshheading:16189667-Humans,
pubmed-meshheading:16189667-Interleukin-4 Receptor alpha Subunit,
pubmed-meshheading:16189667-Male,
pubmed-meshheading:16189667-Polymorphism, Single Nucleotide,
pubmed-meshheading:16189667-Protein Subunits,
pubmed-meshheading:16189667-Receptors, Cell Surface
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pubmed:year |
2005
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pubmed:articleTitle |
Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS.
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pubmed:affiliation |
Service of Infectious Diseases and AIDS Unit, Hospital Clínic de Barcelona, Villarroel, 170, 08036, Barcelona, Spain. asoriano@clinic.ub.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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