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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-9-28
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pubmed:abstractText |
We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-10603400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-11110784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-11181379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-11238649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-11408224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-11528583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-11786922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-12019027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-12065515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-12707265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-12709318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-14506011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-14720406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-15259478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-6702041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-6949641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-7660456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-8700907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-8787918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-8816809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-8977204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-9087498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-9145854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16189135-9234779
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4406-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16189135-Animals,
pubmed-meshheading:16189135-Antimony Potassium Tartrate,
pubmed-meshheading:16189135-Antiprotozoal Agents,
pubmed-meshheading:16189135-Apoptosis,
pubmed-meshheading:16189135-Cell Line, Tumor,
pubmed-meshheading:16189135-Cells, Cultured,
pubmed-meshheading:16189135-Drug Resistance,
pubmed-meshheading:16189135-Inhibitory Concentration 50,
pubmed-meshheading:16189135-Interferon-gamma,
pubmed-meshheading:16189135-Leishmania infantum,
pubmed-meshheading:16189135-Life Cycle Stages,
pubmed-meshheading:16189135-Lipopolysaccharides,
pubmed-meshheading:16189135-Macrophage Activation,
pubmed-meshheading:16189135-Macrophages,
pubmed-meshheading:16189135-Nitric Oxide
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pubmed:year |
2005
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pubmed:articleTitle |
Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.
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pubmed:affiliation |
UR 008 Pathogénie des Trypanosomatidés, IRD (Institut de Recherche pour le Développement), Montpellier, France.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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