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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-20
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pubmed:abstractText |
Adrenergic activation has a central role in the development of HF. The function of the beta1- and the alpha2C-adrenergic receptors is influenced by gene polymorphisms: the beta1Arg389 variant is associated with increased beta1-receptor sensitivity and the alpha2C-receptor Del322-325 variant is associated with decreased alpha2C receptor function and increased norepinephrine release. We hypothesised that these polymorphisms could influence the prevalence of heart failure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1388-9842
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-5
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pubmed:dateRevised |
2011-6-8
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pubmed:meshHeading |
pubmed-meshheading:16188498-Adult,
pubmed-meshheading:16188498-Aged,
pubmed-meshheading:16188498-Aged, 80 and over,
pubmed-meshheading:16188498-Case-Control Studies,
pubmed-meshheading:16188498-DNA,
pubmed-meshheading:16188498-European Continental Ancestry Group,
pubmed-meshheading:16188498-Female,
pubmed-meshheading:16188498-Gene Frequency,
pubmed-meshheading:16188498-Genotype,
pubmed-meshheading:16188498-Heart Failure,
pubmed-meshheading:16188498-Homozygote,
pubmed-meshheading:16188498-Humans,
pubmed-meshheading:16188498-Italy,
pubmed-meshheading:16188498-Male,
pubmed-meshheading:16188498-Middle Aged,
pubmed-meshheading:16188498-Polymerase Chain Reaction,
pubmed-meshheading:16188498-Polymorphism, Genetic,
pubmed-meshheading:16188498-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:16188498-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:16188498-Receptors, Adrenergic, beta-1
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pubmed:year |
2006
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pubmed:articleTitle |
Role of beta1- and alpha2c-adrenergic receptor polymorphisms and their combination in heart failure: a case-control study.
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pubmed:affiliation |
Institute of Cardiology, Department of Experimental and Applied Medicine, University of Brescia, Brescia, Italy. metramarco@libero.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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